The Neutrophil-to-Lymphocyte Ratio at Post-operative Day 3: a Simple Tool to Exclude Clinically Relevant Postoperative Pancreatic Fistula After Pancreatoduodenectomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 648
- 主要终点
- Incidence of clinically relevant pancreatic fistula
研究概览
简要总结
There is still no consensus on whether drain fluid amylase (DFA) level, C-reactive protein (CRP) level, or complex scores predict clinically relevant postoperative pancreatic fistula (CR-POPF). The aim of this study is to determine the accuracy of simple biochemical parameters (leucocytes, neutrophils, lymphocytes, Neutrophil to Lymphocytes Ratio (NLR), at postoperative days 1 and 3) to exclude the diagnosis of CR-POPF.
详细描述
From January 1, 2012 to December 31, 2020, consecutive patients underwent PD performed at Institut Paoli-Calmettes for various pathologies. Data were entered prospectively into a clinical database (NCT02871336).
The cohort was split into 3 groups:
- a training cohort ;
- an internal validation cohort (Paoli Calmettes institute);
- an external validation cohort (Rennes Pontchaillou Hospital).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who underwent pancreatoduodenectomy
排除标准
- •Total pancreatectomy
- •Enucleation
结局指标
主要结局
Incidence of clinically relevant pancreatic fistula
时间窗: at hospital discharge assessed up to 30 days
Clinically relevant postoperative pancreatic fistula according to the 2016 International Study Group of Pancreatic Surgery definition
次要结局
- Biological markers(Postoperative day one and three)