Preoperative Neutrophil-lymphocyte Count Ratio in Prediction of the Grade of Lung Tumor.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Lung Neoplasm
- Sponsor
- Medical University of Silesia
- Enrollment
- 400
- Locations
- 1
- Primary Endpoint
- Neutrophil-lymphocyte count ratio
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
The aim of the study is to assess whether the value of neutrophil-lymphocyte count ratio from the routine preoperative blood test may predict lung tumors' grading.
Detailed Description
Lung cancer remains as one of the leading causes of death among oncology patients. Close connection between inflammation and pathogenesis of some neoplasms was determined in a number of studies. Some studies show promise that ratio of neutrophil to lymphocyte count (NLCR) may be recognized as a prognostic marker for several carcinomas: renal, lung and colorectal. The aim of the study is to assess whether the value of neutrophil-lymphocyte count ratio from the routine preoperative blood test may predict lung tumors' grading. During routine preoperative blood tests complete blood count is done and NLCR, WBC, neutrophil and lymphocyte count is noted. After the thoracic surgery intervention and histopathological examination grading of lung tumor is noted.
Investigators
Piotr Palaczyński
Principal Investigator
Medical University of Silesia
Eligibility Criteria
Inclusion Criteria
- •consecutive thoracic surgery patients with lung cancer grading confirmed by histopathology postoperatively
- •preoperative routine complete blood count analysis
Exclusion Criteria
- •infectious disease
- •pregnancy
- •autoimmunologic disease
- •other known conditions or treatments that may influence the blood count (seropositivity for HIV, chemotherapy, and corticotherapy)
Outcomes
Primary Outcomes
Neutrophil-lymphocyte count ratio
Time Frame: From October 1, 2014 to October 15, 2018
Neutrophil-lymphocyte count ratio is measured during routine preoperative blood tests.
Secondary Outcomes
- Neutrophil count(From October 1, 2014 to October 15, 2018)
- Lymphocyte count(From October 1, 2014 to October 15, 2018)
- Leucocyte count(From October 1, 2014 to October 15, 2018)