NLCR in Prediction of the Grade of Lung Tumor.

Completed

• Conditions: Lung Neoplasm
• Interventions: Diagnostic Test: Complete blood count; Other: Histopathological examination

• Registration Number: NCT03749512
• Lead Sponsor: Medical University of Silesia

Brief Summary

The aim of the study is to assess whether the value of neutrophil-lymphocyte count ratio from the routine preoperative blood test may predict lung tumors' grading.

Detailed Description

Lung cancer remains as one of the leading causes of death among oncology patients. Close connection between inflammation and pathogenesis of some neoplasms was determined in a number of studies. Some studies show promise that ratio of neutrophil to lymphocyte count (NLCR) may be recognized as a prognostic marker for several carcinomas: renal, lung and colorectal. The aim of the study is to assess whether the value of neutrophil-lymphocyte count ratio from the routine preoperative blood test may predict lung tumors' grading. During routine preoperative blood tests complete blood count is done and NLCR, WBC, neutrophil and lymphocyte count is noted. After the thoracic surgery intervention and histopathological examination grading of lung tumor is noted.

Study Timeline

• Study Start: 2014-10-01
• Primary Completion: 2018-10-15
• Status Verified: 2018-11
• Study Completion: 2018-11-16
• Study First Submitted: 2018-11-16
• Study First Submitted QC: 2018-11-20
• Last Update Submitted: 2018-11-20
• Study First Posted: 2018-11-21
• Last Update Posted: 2018-11-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

• consecutive thoracic surgery patients with lung cancer grading confirmed by histopathology postoperatively
• preoperative routine complete blood count analysis

Exclusion Criteria

• infectious disease
• pregnancy
• autoimmunologic disease
• other known conditions or treatments that may influence the blood count (seropositivity for HIV, chemotherapy, and corticotherapy)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Observational Group	Complete blood count	Group of patients with lung tumor qualified for thoracic surgery intervention with routine, preoperative complete blood count test and routine postoperative histopathological examination of lung tumor.
Observational Group	Histopathological examination	Group of patients with lung tumor qualified for thoracic surgery intervention with routine, preoperative complete blood count test and routine postoperative histopathological examination of lung tumor.

Primary Outcome Measures

Name	Time	Method
Neutrophil-lymphocyte count ratio	From October 1, 2014 to October 15, 2018	Neutrophil-lymphocyte count ratio is measured during routine preoperative blood tests.

Secondary Outcome Measures

Name	Time	Method
Neutrophil count	From October 1, 2014 to October 15, 2018	Neutrophil count is measured during routine preoperative blood tests.
Lymphocyte count	From October 1, 2014 to October 15, 2018	Lymphocyte count is measured during routine preoperative blood tests.
Leucocyte count	From October 1, 2014 to October 15, 2018	Leucocyte count is measured during routine preoperative blood tests.

Trial Locations

Locations (1)

Samodzielny Publiczny Szpital Kliniczny nr 1; 🇵🇱 Zabrze, Silesia, Poland