The Effect of Preoperative NLR Level on Epidural Analgesia Application in Thoracotomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- preoperative neutrophil lymphoycte ratio
研究概览
简要总结
The aim of this study is to investigate the relationship of preoperative Neutrophil/Lymphocyte Ratio (NLR) with postoperative pain and the effect of preoperative NLR level on timing of epidural analgesia in thoracotomy.
详细描述
The study was conducted prospectively in 60 patients aged 18-75 years, ASA I-III, who underwent thoracotomy. The patients were divided into 2 groups as NLR level above 2 (Group A) (n:32) and NLR level below 2 (Group B) (n:28). Each group was divided into subgroups with equal numbers of Prempative analgesia group and control group. Local anesthetic was administered to the preemptive analgesia group (Group P) 20 minutes before the surgical incision through the epidural catheter, and to the control group (Group K) 20 minutes before the patient was awakened from the epidural catheter. NRS levels and additional analgesia needs were recorded at 2, 4, 8, 12 and 24 hours postoperatively.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient graded as American Society of Anesthesiologist (ASA) physical status, I, II or III
- •Patient subjected to thoracotomy operation
排除标准
- •Patient having morbid obesity,
- •Patient having renal failure,
- •Patient having hepatic failure,
- •Patient having neuropsychiatric disease,
- •Patient allergy to the study drugs
结局指标
主要结局
preoperative neutrophil lymphoycte ratio
时间窗: 24 hours before the operation
To determine the epidural application with preoperative neutrophil lymphoycte ratio
Postoperative opioid requiremen Postoperative opioid requirement
时间窗: postoperative first 24 hour
Postoperative opioid requirement for pain relief
次要结局
- Numerical Pain Rating Scale(postoperative first 24 hour)
研究者
Ersagun Tugcugil
Assoc.Prof.
Karadeniz Technical University