Effect of Probiotic on Constipation
Phase 3
Completed
- Conditions
- Constipation
- Interventions
- Dietary Supplement: Lactobacillus casei strain Shirota
- Registration Number
- NCT03100851
- Lead Sponsor
- China Agricultural University
- Brief Summary
Constipation is a prevalent intestinal disorder. Lactobacillus casei strain Shirota (LcS) shows potential effect on alleviating constipation. This study evaluated the impact of fermented milk containing LcS on stool consistency and frequency. The stool short chain fatty acid and gut microbiota were also assessed.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 62
Inclusion Criteria
- meet ROME Ⅲ criteria for functional constipation
- normal body mass index between 18.5 and 29.9
Exclusion Criteria
- had a serious disease;
- used systemic antibiotics or antimycotics medication and antidiarrheal or laxative medication in the 30 days prior to the study;
- allergic to milk protein;
- constipated because of organic or neurological lesions;
- participated in any other studies within 2 months prior to this study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description LcS intervention Lactobacillus casei strain Shirota Patients with constipation received dietary supplement with Lactobacaiilus casei strain Shirota.
- Primary Outcome Measures
Name Time Method change of stool consistency change from baseline stool consistency at four-week intervention change of defecation frequency change from baseline defecation frequency at four-week intervention change of constipation-related symptom scores change from baseline constipation-related symptom scores at four-week intervention
- Secondary Outcome Measures
Name Time Method Changes in stool short chain fatty acid content change from baseline stool short chain fatty acid content at four-week intervention Changes in gut microbiota change from baseline gut microbiota at four-week intervention