Effect of Yogurt With Polydextrose,L Acidophilus and B Lactis in Chronic Constipation
- Conditions
- Constipation
- Registration Number
- NCT01825434
- Lead Sponsor
- University of Campinas, Brazil
- Brief Summary
Background and aims:Constipation is a frequent complaint and the combination of a prebiotic and probiotics would have a potentially synergic effect on the intestinal transit. The present study therefore aims to investigate the combination of polydextrose (Litesse®), L. acidophilus NCFM® and B. lactis HN019 in a yogurt on intestinal transit in subjects who suffer from constipation.
Methods: Patients with constipation were randomly divided into two groups, Placebo Group (PG) and Treatment Group (TG), and had to eat 180 ml of unflavored yogurt every morning for 14 days. Those in the CG received only yogurt, while the TG received yogurt containing polydextrose, L. acidophilus NCFM® (ATCC 700396) and B. lactis HN019 (AGAL NM97/09513). Expect that patients who took a combination of polydextrose has a decrease in the colonic transit time (CTT) when comparing initial and final transit time.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 30
- Patients with chonic constipation
- agachan between 10 and 20
- bowel transit time with ingestion of 24 radiopaque markers (Sitzmarks) and retention of 80% of them on day 5
- Patients with hypothyroidism
- antidepressant users
- normal colonic
- transit time (24 hrs or less) as well as higher than 96 hours were
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Colonic transit Colonic transit time and Agachan score will be evaluated before and in day15 aftler yogurt ingestion. All particIpants will be followed for 30 days after the end of study
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Campinas
🇧🇷Campinas, São Paulo, Brazil