Posterior Circulation ASTRAL Prognostic Score

Active, not recruiting

• Conditions: Stroke Ischemic; Stroke Acute; Posterior Circulation Brain Infarction; Risk Score
• Interventions: Diagnostic Test: ASTRAL prognostic score

• Registration Number: NCT05906420
• Lead Sponsor: University of Thessaly

Brief Summary

The goal of this study is to develop a prognostic score for ischemic posterior circulation strokes, based on our previous work on with the ASTRAL scores (Acute STroke Registry and Analysis of Lausanne) on overall stroke prognosis, intracranial occlusion, recanalization and stroke recurrences. The main question it aims to answer is the modified Rankin score in 3 months after the event.

Participants will be patients with acute ischemic stroke of the posterior circulation with mRS priot to event \<3. All the data will be collected retrospectively from patients included in the ASTRAL registry between January 2003 and December 2021. The ASTRAL registry will be used as the derivation cohort of the score. Demographics, acute glucose, NIHSS score and acute imaging of each participant will be used from the derivation cohort in order to create an integer-based prognostic score. After internal validation, we plan to validate the score in external stroke registries to show its validity.

Detailed Description

Not available

Study Timeline

• Study Start: 2003-01-01
• Primary Completion: 2021-12-31
• Study First Submitted: 2023-06-06
• Study First Submitted QC: 2023-06-06
• Study First Posted: 2023-06-15
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-03
• Last Update Posted: 2025-04-08
• Study Completion: 2025-11-24

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 2000

Inclusion Criteria

• Isolated posterior circulation strokes based on clinical or/and imaging evidence.
• Arriving within 24h at hospital since last proof of good health.

Exclusion Criteria

• no available data for 3 months modified Rankin Score
• modified Rankin Score≥3 prior the event

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
ASTRAL	ASTRAL prognostic score	-

Primary Outcome Measures

Name	Time	Method
3 months modified Ranking scale	January 2003-December 2021	evaluation of 3 months neurological disability

Trial Locations

Locations (2)

First Propedeutic Department of Internal Medicine & Stroke Unit, AHEPA University Hospital, Aristotle University of Thessaloniki; 🇬🇷 Thessaloniki, Central Macedonia, Greece

Stroke Center, Department of clinical neurosciences, Lausanne University Hospital and University of Lausanne; 🇨🇭 Lausanne, Vaud canton, Switzerland