TGFB1 And LAMA1 Gene Polymorphisms in High Myopia
Not Applicable
Completed
- Conditions
- Gene MutationsHigh Myopia
- Interventions
- Genetic: TGFB1 AND LAMA1 GENE POLYMORPHISMS
- Registration Number
- NCT03451877
- Lead Sponsor
- Ege University
- Brief Summary
The investigators aimed to investigate TGFB1 and LAMA1 gene polymorphisms in children with high myopia in order to determine the genetic basis of large myopic shifts causing severe visual impairment and complications.
Seventy-four children with high myopia (≥6 diopters \[D\]; study group) and 77 emmetropic children (±0.5D; control group) were included. Genetic and polymorphism analyses were performed in the Medical Genetics Laboratory using DNA purified from the patients' blood samples.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 151
Inclusion Criteria
- Patients under the age of 13
- Patients with cycloplegic refraction values ≥6 D (for study group)
- Emmetropic patients (for control group)
Exclusion Criteria
- Patients who had additional ocular pathology that may affect refraction (such as glaucoma, cataracts, corneal disease)
- Patients with history of ocular surgery
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Control group TGFB1 AND LAMA1 GENE POLYMORPHISMS Emmetropic children TGFB1 AND LAMA1 GENE POLYMORPHISMS were examined Study group TGFB1 AND LAMA1 GENE POLYMORPHISMS Children with cycloplegia refractive error more than -6 D TGFB1 AND LAMA1 GENE POLYMORPHISMS were examined
- Primary Outcome Measures
Name Time Method Genetic basis of high myopia 4 years evaluated polymorphisms in the LAMA1 (rs2089760) and TGFB1 (rs4803455) genes in children younger than 13 years of age with ≥6 D myopia
- Secondary Outcome Measures
Name Time Method