Immunity to varicella-zoster virus in immunocompromised renal disease patients - Immunity to VZV in renal disease

niversitair Medisch Centrum Groningen0 个研究点目标入组 210 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

暂无简介。

•In order to be eligible to participate in this study, a patient must meet all of the following criteria:
•* Provision of written informed consent
•* *18 years of age
•* For the first part of the study, dependent on which group the participant is included in:
•o Receiving renal replacement therapy *1 time per week, or
•o Presence of stored blood samples before and after kidney transplantation in existing Biobank
•* For the second part of the study: VZV seronegativity
•o Subject is a VZV seronegative pre-renal transplantation patient and
•o Intended administration of VZV vaccine Provarivax;For healthy controls, the following criteria must be met:
•* Provision of written informed consent
•* *18 years of age

•A potential subject who meets any of the following criteria will be excluded from participation in this study:
•* Pregnancy
•* Malignancy (at present or <2 years ago), except for skin malignancies;For patients receiving renal function replacement therapy:
•* Underlying auto-immune disorder as cause for need renal function replacement therapy
•* Use of immunosuppressive medication other than *7.5 mg prednisolone/day, or immunostimulatory medication
•* Less than 3 months duration of renal replacement therapy;For participants receiving VZV vaccination, the second part of the study:
•* No administration of VZV vaccine Varivax due to any reason

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