Comparison of insertion conditions of a laryngeal mask airway under propofol-ketamine or propofol-fentanyl anesthesia
- Conditions
- ASA 1 and 2 adults scheduled for elective surgical procedures under general anesthesia
- Registration Number
- CTRI/2014/08/004905
- Lead Sponsor
- Institute
- Brief Summary
This was a double-blinded,randomized, controlled study, conducted in adult, ASA 1 and 2 patients,undergoing elective surgical procedures. 120 patients, satisfying the inclusionand exclusion criteria, were randomly allocated into two groups,propofol-ketamine (PK) and propofol-fentanyl (PF), each group consisting of 60patients, by sealed envelope technique. The study was designed to compare thehemodynamic responses to induction & insertion of LMA and the insertionconditions between propofol- ketamine and propofol- fentanyl combinations.
All patients received 0.3mg Glycopyrrolate, intramuscular,half an hour before the procedure. Inthe operating room, after recording the baseline parameters- oxygen saturation(SpO2), Mean Blood Pressure (BP), Pulse Rate (PR) and End Tidalcarbon dioxide (EtCO2), 1µg/ kg Fentanyl to the PF group & 0.5mg/kg Ketamine to the PK group was given intravenously. Induction of anesthesiawas initiated with 1% Propofol @ 1mg/ kg/ min with a syringe pump, till thepatient tolerated a full jaw thrust, which was considered as the end point forLMA insertion. On reaching the end point, LMA insertion was attempted throughthe classical approach, as described by Brain. Proper position of LMA wasascertained by the ability to easily ventilate the lungs (assessed by chestmovement), without any significant resistance or leak and no significantresistance to expiration with rapid refilling of the reservoir bag. Acapnograph was also used to assess adequacy of ventilation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 120
ASA 1 and 2 adults scheduled for elective surgical procedures under general anesthesia.
- Contraindication for LMA usage 2.
- History of allergic reactions to any of the study drugs.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Differences in insertion conditions for LMA insertion as assessed by a 6 variable, 3 point LMA insertion score Induction of general anesthesia and LMA insertion
- Secondary Outcome Measures
Name Time Method Hemodynamic responses (blood pressure and heart rate) to LMA insertion Upto 10 minutes following insertion of LMA
Trial Locations
- Locations (1)
Dept of Anesthesiology & Critical Care
🇮🇳Pondicherry, PONDICHERRY, India
Dept of Anesthesiology & Critical Care🇮🇳Pondicherry, PONDICHERRY, IndiaDr Satyen ParidaPrincipal investigator9940973502jipmersatyen@gmail.com