Detecting the Rest Tremor Associated With Parkinson's Disease Using Analysis of the Muscle Contractions Rhythmicity
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- rhythmicity index
研究概览
简要总结
Resting tremors associated with Parkinson's disease (PD) remains difficult to quantify and track during disease progression. This study propose to explore the rhythmicity of distal muscle contractions in the upper limb to characterize resting tremor and discriminate it from cerebellar tremor (CT) based on the frequency spectrum of the EMG signal.
详细描述
This retrospective study analyzed surface EMG recordings of wrist flexor-pronators and extensor-supinators from patients with PD or CT bilaterally in five 10-second conditions: rest with contralateral motor distraction, symmetrical arms extended forward posture with hands pronated, semi-pronation, supination, and elbows flexed with hands pronated. The rhythmicity index (RI) is calculated from the ratio of the area of the maximum power peak to the total area of the spectrum between 1.5-12Hz.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patient who performed surface EMG recordings of wrist flexor-pronators and extensor-supinators in Laboratories;
- •diagnosis of Parkinson's disease or cerebellar tremor.
排除标准
- •Botulinium toxin injection in upper limb during a delay of 3 months before surface EMG recordings;
- •Levodopa drugs administrated during a delay of 12 hours before surface EMG recordings;
- •Tremor-favour drugs administrated during a delay of 30 days before surface EMG recordings;
- •Presence of an other neurologic disease or of any disease associated with motor disorders in upper limb.
结局指标
主要结局
rhythmicity index
时间窗: 10 seconds
The rhythmicity index (RI) is calculated from the ratio of the area of the maximum power peak to the total area of the spectrum between 1.5-12Hz.
次要结局
未报告次要终点
研究者
Emilie Hutin
Co-director of laboratory
Henri Mondor University Hospital