Detecting the Rest Tremor Associated With Parkinson's Disease Using Analysis of the Muscle Contractions Rhythmicity

Recruiting

• Conditions: Parkinson; Cerebellar Tumor; Rest Tremor; Diagnoses Disease; Movement; Abnormal, Involuntary
• Interventions: Diagnostic Test: EMG in wrist flexor-pronators and extensor-supinators

• Registration Number: NCT05998486
• Lead Sponsor: Henri Mondor University Hospital

Brief Summary

Resting tremors associated with Parkinson's disease (PD) remains difficult to quantify and track during disease progression. This study propose to explore the rhythmicity of distal muscle contractions in the upper limb to characterize resting tremor and discriminate it from cerebellar tremor (CT) based on the frequency spectrum of the EMG signal.

Detailed Description

This retrospective study analyzed surface EMG recordings of wrist flexor-pronators and extensor-supinators from patients with PD or CT bilaterally in five 10-second conditions: rest with contralateral motor distraction, symmetrical arms extended forward posture with hands pronated, semi-pronation, supination, and elbows flexed with hands pronated. The rhythmicity index (RI) is calculated from the ratio of the area of the maximum power peak to the total area of the spectrum between 1.5-12Hz.

Study Timeline

• Study Start: 2023-04-03
• Status Verified: 2023-08
• Study First Submitted: 2023-08-07
• Study First Submitted QC: 2023-08-16
• Last Update Submitted: 2023-08-16
• Study First Posted: 2023-08-21
• Last Update Posted: 2023-08-21
• Primary Completion: 2023-09-30
• Study Completion: 2023-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• patient who performed surface EMG recordings of wrist flexor-pronators and extensor-supinators in Laboratories;
• diagnosis of Parkinson's disease or cerebellar tremor.

Exclusion Criteria

• Botulinium toxin injection in upper limb during a delay of 3 months before surface EMG recordings;
• Levodopa drugs administrated during a delay of 12 hours before surface EMG recordings;
• Tremor-favour drugs administrated during a delay of 30 days before surface EMG recordings;
• Presence of an other neurologic disease or of any disease associated with motor disorders in upper limb.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Tremor of rest	EMG in wrist flexor-pronators and extensor-supinators	Patient with a diagnosis of Parkinson's disease and who performed surface EMG recordings of wrist flexor-pronators and extensor-supinators analysis in Laboratories
Cerebellar tremor	EMG in wrist flexor-pronators and extensor-supinators	Patient with a diagnosis of cerebellar tremor and who performed surface EMG recordings of wrist flexor-pronators and extensor-supinators analysis in Laboratories

Primary Outcome Measures

Name	Time	Method
rhythmicity index	10 seconds	The rhythmicity index (RI) is calculated from the ratio of the area of the maximum power peak to the total area of the spectrum between 1.5-12Hz.

Trial Locations

Locations (1)

Laboratoire Analyse et Restauration du Mouvement; 🇫🇷 Créteil, France