ong-Term Early Development Research: serum-biomarkers for cerebral damage as predictors for neurocognitive deficits and for the course of neurocognitive development of children after cardiopulmonary resuscitatio

Recruiting

• Conditions: Q21.0; Q21.3; T98.3; T88.8; R62.9; Ventricular septal defect; Q24.9; Sequelae of complications of surgical and medical care, not elsewhere classified; Q20.3; Tetralogy of Fallot

• Registration Number: DRKS00013639
• Lead Sponsor: Deutsches Herzzentrum Berlin

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-12-21
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• CPR =5min
• Hospitalization at DHZB after CPR
• Consent of parents/legal guardian
• German mother tongue of at least one parent

Exclusion Criteria

•No consent of parents/legal guardian
•Pre-existing, not differentially diagnosed neurocognitive deficits
•Known or suspected retardation syndromes
•Known drug and/or alcohol abuse of the mother during pregnancy.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The motoric, cognitive and language development as measured with the Bayley III Scale/ WPPSI-III/ WISC-IV at 6, 12, 24, 36 months after CPR.

Secondary Outcome Measures

Name	Time	Method
• Mortality <br>• Neurological status at discharge from hospital as measured with the PCPC (Pediatric Cerebral Performance Category Scale) and PSOM-SNE (Pediatric Stroke Outcome Measure Short Neuro Exam)<br>• Morbidity and Organ dysfunction (renal failure, liver damage, heart failure, nutritional disorder)<br>