Quality of Awakening and Impact on Cognitive Function After Administration of Sugammadex in Robotic Radical Cystectomy
- Conditions
- Anesthesiology Management
- Interventions
- Registration Number
- NCT02454504
- Lead Sponsor
- Regina Elena Cancer Institute
- Brief Summary
With the aim of enhancing the quality of surgery, the robotic cystectomy is often conducted using continuous intravenous infusion of curare, which ensures maximum neuromuscular relaxation until the end of the intervention. Sugammadex, administered for the reversal of deep neuromuscular blocked, enable rapid awakening. Moreover, Sugammadex seems to have a positive effect also on the recovery of cognitive function, psychomotor coordination and mental ability, effects undocumented in Literature.
The aim of the investigators study was to assess whether the reversal with sugammadex after intraoperative continuous infusion of rocuronium, can improve the quality of awakening.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 120
- ASA score ≤ III
- Patients underwent robotic cystectomy
- Cerebrovascular disease
- BMI ≥ 30
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description sugammadex sugammadex this arm will receive sugammadex at the end of the surgery neostigmine Neostigmine this arm will receive neostigmine at the end of the surgery
- Primary Outcome Measures
Name Time Method average score obtained on awakening according to specific test 16 months cognitive function as assessed by the Mini Mental State Exam; quality of awakening as assessed by the Observer's Assessment of Alterness/sedation
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Regina Elena Cancer Institute
🇮🇹Rome, RM, Italy