Perioperative Enhancement of Cognitive Trajectory (The PROTECT trial)

Not Applicable

Recruiting

• Conditions: Delirium; Postoperative Neurocognitive Disorder; Mild Neurocognitive Disorder; Major Neurocognitive Disorder; Anaesthesiology - Anaesthetics; Neurological - Neurodegenerative diseases; Public Health - Health promotion/education; Surgery - Other surgery; Mental Health - Studies of normal psychology, cognitive function and behaviour

• Registration Number: ACTRN12619001778178
• Lead Sponsor: The University of Melbourne

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-12-16
• Last Update Posted: 6 June 2022

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 692

Inclusion Criteria

1. Patients aged 65 years or older, scheduled for cardiac or non-cardiac surgery, requiring at minimum, one night hospital stay
2. Reside within a reasonable proximity to St Vincent's Hospital Melbourne to facilitate neuropsychology follow up and participation with intervention strategies.
3. Capacity to provide written informed consent

Exclusion Criteria

1. Prior neurological injury or insult (e.g., major traumatic brain injury)
2. Contraindication to neuropsychological testing such as language, visual or hearing impairment
3. Associated medical problems that may lead to significant complications and subsequent loss to follow or inability to engage with prehabilitation activities.
4. Patients unable to consent independently to their surgery on account of cognitive impairment

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Postoperative Neurocognitive Disorder; assessed with a battery of neuropsychological tests that our research team has been using to assess PND for over 15 years. <br>This battery comprises, the Trail Making Test (TMT), CERAD Word Learning test, Digit Symbol Substitution test, Controlled Oral Word Association test (COWAT), Grooved Pegboard test, Clock Drawing, Wechsler Test of Adult Reading (WTAR) and the Montreal Cognitive Assessment (MoCA), [3 months post operatively ]