Comparing the effect of propofol and isoflurane-based general anaesthesia on cognitive skills of elderly patients
Not Applicable
- Registration Number
- CTRI/2019/05/019276
- Lead Sponsor
- Maulana Azad Medical College
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients of American Society of Anaesthesiologists (ASA) physical status grades I/II/II requiring surgeries with expected duration of anaesthesia > 2hours
Exclusion Criteria
Patients unable to comprehend the required cognitive assessment tests
Hindi Mental State Examination score less than or equal to 26 preoperatively
Known cases of any psychiatric illness
History of cerebrovascular accident
Known disorder affecting cognition
Known history of alcohol or drug abuse
Deranged kidney function tests
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of Postoperative Cognitive Dysfunction as assessed by Hindi Mental State Examination, Digit Span test and Digit Symbol Substitution Test, when there is at least 20% change from baseline values in at least 2 of these tests.Timepoint: 24 hours postoperatively
- Secondary Outcome Measures
Name Time Method Proportion of patients showing at least 20% change from baseline values in individual assessment testsTimepoint: 24 hours postoperatively;Sensitivity of the three tests in detecting POCDTimepoint: 24 hours postoperatively