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Clinical Trials/NCT04639856
NCT04639856
Completed
Not Applicable

ICU Stay in Patients With Low Ejection Fraction Undergoing Cardiac Revascularization: Comparison of On-pump vs Off-pump Coronary Artery Bypass Grafting

Armed Forces Institute of Cardiology, Pakistan1 site in 1 country60 target enrollmentJuly 15, 2018

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Cardiac Revascularization
Sponsor
Armed Forces Institute of Cardiology, Pakistan
Enrollment
60
Locations
1
Primary Endpoint
ICU Stay
Status
Completed
Last Updated
5 years ago

Overview

Brief Summary

Coronary artery bypass graft (CABG) surgery can result in severe postoperative complications, such as renal and pulmonary failure. In about 80% of the cases worldwide, it is currently performed with cardiopulmonary bypass (CPB) with cardiac arrest. Cardiopulmonary bypass leads to a systemic inflammatory response, which may be induced by the contact of circulating blood with artificial surfaces of the extracorporeal circuit.[1] To reduce postoperative complications caused by systemic inflammation, off-pump CABG was reintroduced into clinical practice in the early 1990s. During off-pump surgery, the coronary artery grafts are placed on coronaries of a beating heart, thereby avoiding aortic cross clamping and CPB. [1] There are many studies and debates about the two approaches to cardiac revascularization via CABG. This study aims to answer the question as to difference in the ICU stay of patients with low ejection fraction undergoing cardiac revascularization bet ween off pump and on pump coronary artery bypass grafting and better treatment option shall be adopted in future.

Registry
clinicaltrials.gov
Start Date
July 15, 2018
End Date
January 15, 2019
Last Updated
5 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
Armed Forces Institute of Cardiology, Pakistan
Responsible Party
Principal Investigator
Principal Investigator

Muhammad Bilal

Cardiac Surgeon

Armed Forces Institute of Cardiology, Pakistan

Eligibility Criteria

Inclusion Criteria

  • All patients of either gender between the ages of 40 to 80
  • Ejection fraction of less than or equal to 35% undergoing CABG.
  • undergoing CABG.

Exclusion Criteria

  • Patients with ejection fraction of more than 35%
  • Patients with previous history of cardiac revascularization
  • Patients with previous history of chronic kidney disease and obstructive sleep apnea.

Outcomes

Primary Outcomes

ICU Stay

Time Frame: 6 Months

post operative ICU stay in patients undergoing cardiac revascularization

Study Sites (1)

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