Enhancing Recovery After Cardiac Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 808
- 试验地点
- 10
- 主要终点
- Levels of proinflammatory cytokines (IL-1 and IL-6)
研究概览
简要总结
Patients recovering from coronary artery bypass graft (CABG) surgery have high rates of depression, and depression is associated with higher risk of complications and death. Recent discoveries show that depression involves changes in certain molecules in the blood, which are also involved in progressive coronary artery disease (CAD) and its complications. This study will evaluate the effects of cognitive behavioral therapy (CBT) as a treatment for depression on these biological markers among CABG patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 45 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Undergone CABG at one of our recruitment sites
排除标准
- •Less than 45 years of age
- •Have cognitive impairment or major comorbid psychiatric conditions
- •Have autoimmune disorder or malignancy
- •Currently smoking
结局指标
主要结局
Levels of proinflammatory cytokines (IL-1 and IL-6)
时间窗: at baseline and after 8 weeks (at the completion of the intervention)
The soluble receptor for IL-6 (sIL-6)
时间窗: at baseline and after 8 weeks (at the completion of the intervention)
Inflammatory markers c-reactive protein (CRP and sICAM-1)
时间窗: at baseline and after 8 weeks (at the completion of the intervention)
次要结局
- Depression symptoms (Beck Depression Inventory)(at baseline and after 8 weeks (at the completion of the intervention))
- Presence of clinical depression(at baseline and after 8 weeks (at the completion of the intervention))
- Pain(at baseline and after 8 weeks (at the completion of the intervention))
- Sleep disturbances(at baseline and after 8 weeks (at the completion of the intervention))
研究者
Belinda Chen
Project Director
University of California, Los Angeles