Controllability estimation in Parkinson's disease: role of dopamine

• Conditions: eurological disorder; Parkinson's disease

• Registration Number: NL-OMON56646
• Lead Sponsor: Radboud Universiteit Nijmegen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

• Age >= 18 years
• Disease duration <= 10 years
• Use L-DOPA to treat their symptoms

Exclusion Criteria

o Have been part of the Personalized Parkinson*s Project
o Taking any other dopaminergic medication to treat their symptoms (except
decarboxylase inhibitor)
o Negative indications for MRI
o Incompatible medical devices (e.g. pacemaker)
o Incompatible metal implants
o Claustrophobia

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Behavioral estimation of controllability between study sessions and BOLD<br /><br>response differences related to behavioral manipulations of the task between<br /><br>study sessions.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Correlation of controllability estimation and cortisol levels as measured by<br /><br>saliva samples.</p><br>