Quantification of Parkinson*s Disease motor symptoms using the PowerGlove
Completed
- Conditions
- Parkinson's diseasePD10028037
- Registration Number
- NL-OMON40878
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 35
Inclusion Criteria
- The patient has had Parkinson's symptoms for more than five years.
- The patient has a good response to dopaminergic medication.
- The patient is selected to undergo preoperative screening for Parkinson DBS surgery in the Academic Medical Center, Amsterdam.
- The patient is able to communicate adequately in Dutch or English.
- The patient is between the age of 18 and 80.
Exclusion Criteria
- The patient has a medical (or other) history other than Parkinson's disease which restricts hand movement (e.g. a complicated wrist fracture of severe arthritis).
- Inability to correctly place the PowerGlove on the patient's hand or to correctly perform the necessary calibration.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary study parameters in this study are the sensitivity, specificity and<br /><br>reliability of the PowerGlove system in measuring the Parkinson symptoms<br /><br>rigidity, bradykinesia and tremor.<br /><br>These are derived from the relations between:<br /><br><br /><br>- moment of force and range of motion generated in passive wrist flexion,<br /><br>measured by the PowerGlove system,<br /><br>- speed and amplitude of hand and finger kinematics in different active hand<br /><br>movement tasks, measured by the PowerGlove system,<br /><br>- frequency characteristics and amplitude of hand movement in rest, measured by<br /><br>the PowerGlove system,<br /><br><br /><br>and<br /><br><br /><br>- UPDRS scores for rigidity, bradykinesia and tremor, assessed by an<br /><br>experienced clinician (UPDRS part III, items 20-25)<br /><br><br /><br>in different points over time, ON- and OFF-medication, and executed by<br /><br>different experienced clinicians.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary study parameters of interest are:<br /><br>- EMG activity recorded during passive wrist flexion.<br /><br>- Gender<br /><br>- Age<br /><br>- Disease duration<br /><br>- Medication use<br /><br>- Dominant left of right hand<br /><br>- Body weight<br /><br>- Body length<br /><br>- Hand size</p><br>