DiPAR: Diagnosing Parkinson*s Disease by neuromuscular function evaluatio

Completed

Conditions: movement disorders
Parkinson's disease
10028037

Registration Number: NL-OMON38380

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 90

Inclusion Criteria

All subjects
- right*handed
- informed consent
- ability to hold a pen for at least half an hour
PD patients
- diagnosis according to the UK Parkinson*s Disease Society Brain Bank clinical diagnostic criteria
- symptoms scored as Hoehn & Yahr I*III
- age: >50 years
Essential tremor
- diagnosis according to the criteria defined by the Tremor Investigation Group for more than 5 years
Enhanced physiological tremor
- diagnosis based on polymyography
Psychogenic tremor
- diagnosis based on polymyography
Dystonia (writer*s cramp or torticollis spasmodica)
- clinical diagnosis of dystonia
- last botulinum toxin treatment at least 2 months prior to study investigation
Post*stroke spasticity
- clinical diagnosis of post*stroke spasticity (afflicting at least right hand function)

Exclusion Criteria

All subjects
- (other) neurological or motor disorder (than that included for)
- Mini Mental State Examination (MMSE) score <26
- Use of medication influencing movement other than for Parkinson's disease or essential tremor
PD patients
- Not willing to comply with overnight-withdrawal of Parkinson-related medication
- Tremor-dominant PD
ET patients
- Not willing to comply with medication withdrawal, starting 7 days prior to study investigation

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Pen tip motion, velocity and acceleration and pen grip forces (in the time and<br /><br>frequency domain) during each of the tasks, compared between groups. In<br /><br>addition mean EMG, EMG variability and EMG power peaks will be assessed.</p><br>

Secondary Outcome Measures