Biomarkers for differentiation of Parkinson*s disease subtypes.

Recruiting

Conditions: Parkinson's
10028037

Registration Number: NL-OMON39292

Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 210

Inclusion Criteria

For all participants a minimum age of 18 years is required.
All PD patients must fulfill the United Kingdom Parkinson*s Disease Society Brain Bank criteria for idiopathic PD. Patients with Lewy body dementie (DLB) must fulfill the McKeith DLB criteria and all patients must be diagnosed with PD or DLB by a movement disorder specialist.
Only patients who are mental competent are included.

Exclusion Criteria

Participants with a contraindication for MRI are excluded.
Patients who underwent stereotactic surgery were excluded.
Controls with a disease of the central nervous system are excluded.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters of this study will include magnetic resonance imaging<br /><br>(MRI) parameters, and clinical measures. Clinical data include important<br /><br>demographic and disease-related characteristics as well as measures for disease<br /><br>severity, and the important motor (motor functioning and motor complications),<br /><br>and non-motor domains (cognition, depression, psychotic symptoms, sleep<br /><br>problems, and autonomic dysfunction). The combination of clinical scores will<br /><br>allocate PD patients in one of the four subtypes. MRI will be carried out on a<br /><br>3T scanner and will include volumetric, diffusion, and functional MRI<br /><br>parameters. </p><br>

Secondary Outcome Measures