Comparison of two adjunctive locally delivered antibiotic gel regimens for initial therapy in periodontitis patients
- Conditions
- Oral HealthTopical antibiotic gels applied adjunctively to subgingival instrumentation in stage III-IV periodontitis patients.
- Registration Number
- ISRCTN89207035
- Lead Sponsor
- MegaGen Dental Implant Romania
- Brief Summary
2023 Results article in https://pubmed.ncbi.nlm.nih.gov/36837504/ (added 20/04/2023)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 100
1. All subjects were diagnosed with periodontitis stage III and IV
2. All participants fulfilled the following inclusion criteria:
2.1. Aged between 25 and 80 years old
2.2. At least 8 sites with PD = 5 mm and showing bleeding on probing
2.3. Clinical attachment loss =3 mm
2.4. Patients who have not undergone periodontal therapy in the last 12 months
Patients with the following conditions were excluded:
1. Clinically relevant psychiatric disorders
2. Alcohol consumption
3. Autoimmune disorders
4. HIV infection
5. Untreated diabetes mellitus
6. Pregnancy or breastfeeding
7. Patients who have received periodontal therapy in the last 12 months
8. Patients who reported local and/or systemic antibiotic therapy within the 3 months before the baseline examination of the study
9. Candidiasis
10. Allergies to piperacillin, tazobactam, doxycycline, or to any tetracycline or penicillin or to any excipient of the products used
11. Systemic medication that can influence the clinical features of periodontitis
12. Patients who have rinsed or irrigated with antiseptics less than a month before the initial examination
12. Conditions that require antibiotic protection
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Periodontal pocket depth measured using a periodontal probe at baseline (initial evaluation) and 3 and 6 months after surgery
- Secondary Outcome Measures
Name Time Method