Randomized interventiOn of Biventricular Pacemaker Function on ventrIcular Function Among Patients With mechaNical Circulatory Support Devices
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 22
- Locations
- 1
- Primary Endpoint
- Peak Vo2
Study Overview
Brief Summary
The primary reason the investigators are doing this study are to understand how the right side of the heart functions in heart failure patients with left ventricular assist devices (LVADs, or "mechanical hearts"). Second, the investigators are interested in understanding how different pacemaker settings influence function of the heart at rest and activity.
Detailed Description
Healthy individuals, as well as patients with advanced heart failure supported by LVADs, completed invasive hemodynamic analysis at rest and with exercise to characterize right-sided heart function at rest and with exercise during invasive cardiopulmonary exercise testing on upright cycle ergometry.
Study Design
- Study Type
- Observational
- Observational Model
- Other
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Peak Vo2
Time Frame: 20 minutes
peak Vo2 measured by indirect calorimetry during cardiopulmonary exercise testing
Cardiac Output
Time Frame: 20 minutes
cardiac output measured during invasive cardiopulmonary exercise testing.
Secondary Outcomes
- Minute Ventilation(20 minutes)
- Blood Pressure(20 minutes)
- EES/EA(20 minutes)
- Tau(20 minutes)
- Stroke Work(20 minutes)
- Respiratory Exchange Ratio(20 minutes)