The Acute Effects of Energy and Carbohydrate Restriction on Postprandial Metabolism
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Glucose Concentration
研究概览
简要总结
Most individuals spend the majority of the day in a fed state, making postprandial blood glucose and lipid regulation a central component of metabolic health. Short periods of fasting or reduced carbohydrate intake can occur frequently in daily life, whether through intentional dietary practices (e.g. intermittent fasting), cultural or religious traditions, or unstructured eating patterns. These periods can induce measurable metabolic changes, but the acute effects of a single 24-hour period of fasting or carbohydrate restriction on postprandial metabolism upon refeeding remain poorly characterised.
This study will examine how 24 hours of either complete fasting or low carbohydrate intake without energy restriction influence postprandial blood glucose and lipid concentrations, as well as related metabolic markers, in healthy adults, in comparison to a habitual high carbohydrate control diet. Participants will complete all three conditions in a randomised order, consuming a standardised meal test after each 24-hour condition. Repeated blood sampling and gas exchange measurements will be carried out to assess postprandial metabolic responses.
The aim of this study is to characterise whether acute periods of fasting and low carbohydrate restriction elicit distinct or comparable alterations in postprandial metabolic responses. A clearer understanding of these acute physiological effects can help inform how variations in eating patterns influence glucose and lipid handling in individuals without metabolic disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged between 18-40 years
- •Have a BMI of 18.5-29.9 kg/m2
排除标准
- •Diagnosed with any major chronic conditions (e.g. type 2 diabetes, coronary heart disease, cancer, chronic kidney disease, etc.)
- •Use of medication that may interfere with study outcomes (e.g. glucose or lipid-lowering medications)
- •Currently or recently pregnant (within last 6 months), planning to get pregnant or currently lactating
- •Has a habitually low carbohydrate intake (<150g carbohydrates/day)
- •Current or previous eating disorder
- •Has donated more than 500ml of blood in the last 3 months prior to the initial laboratory visit
- •Insufficient mental capacity or language skills to independently understand and follow the study protocol
- •Has an irregular sleeping pattern (e.g. due to undertaking night-shift work)
- •Any other condition, concurrent intervention or behaviour deemed either to pose undue personal risk to the participant or to introduce bias into the experiment
研究组 & 干预措施
Habital control diet
100% of energy requirements, ≥150 carbohydrate/day
Fasting
No energy intake
干预措施: Fasting (Behavioral)
Carbohydrate Restriction
100% of energy requirements, ≤20g carbohydrate
干预措施: Carbohydrate restriction (Behavioral)
结局指标
主要结局
Glucose Concentration
时间窗: After each 24-hour dietary condition
Plasma glucose concentrations assessed at baseline and postprandially for 2 hours after a mixed meal test
Triglyceride Concentration
时间窗: After each 24-hour dietary condition
Plasma triglyceride concentrations assessed at baseline and postprandially for 2 hours after a mixed meal test
次要结局
- Insulin Concentration(After each 24-hour dietary condition)
- Non-esterified Fatty Acid Concentration(After each 24-hour dietary condition)
- Beta-hydroxybutyrate Concentration(After each 24-hour dietary condition)
- Substrate Oxidation(After each 24-hour dietary condition)
研究者
Guoda Karoblyte
Doctoral Researcher
University of Bath