Large-scale ex Vivo Expansion and Characterization of Two Kinds of MSC From Knee for Clinical Application
- Conditions
- Knee Injuries
- Registration Number
- NCT02386163
- Lead Sponsor
- EMO Biomedicine Corporation
- Brief Summary
According to many researches, mesenchymal stem cells (MSC) isolated from synovial membrane and infrapatellar fat pad have higher ex vivo proliferation capacity, multipotency and ability to undergo chondrogenesis.
Based on this concept, the investigators plan to get two removed tissues (synovial membrane and infrapatellar fat pad) from patients who have an operation of TKR (Total Knee Replacement). The investigators are going to isolate and expand MSC from these two tissues respectively, and then compare their characterization and potential for clinical application. In the other hand, the investigators plan to build techniques and procedures which comply with "Good Tissue Practices (GTP)".
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 6
Patient who have an total knee replacement surgery
Patient who don't sign the agreement
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Compare MSCs from synovial membrane and infrapatellar fat pad 2 months Comparison items include doubling time, phenotype, chondrogenesis and biological activity.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Far Eastern Memorial Hospital
🇨🇳New Taipei City, Taiwan