Effects and costs of a combined screening and treatment program for elderly (aged 75 years and over) with depressive symptoms in general practice

• Conditions: depressed mood; depression; depressive symptoms; 10027946

• Registration Number: NL-OMON30250
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 4000

Inclusion Criteria

Inclusion criteria for screening: elderly aged 75 years and over enlisted in general practices. Inclusion criteria for treatment-offer: screen positive for depression (GDS-15 > 4).

Exclusion Criteria

Exclusion criteria for screening: terminal illness (life expectancy < 3 months), current treatment for depression, loss of partner/important relative < 3 months ago and MMSE < 19 (confirmed in secondary care).
Exclusion criteria for treatment-offer: severe cognitive impairment (MMSE < 19).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome is the difference in severity of depressive symptoms as<br /><br>measured with the Montgomery-Asberg Depression Rating Scale (MADRS) between 0<br /><br>and 6 months in patients in the intervention arm versus usual care patients. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcome measures (at 6 and 12 months) are differences in percentage<br /><br>of responders, quality of life, use of (in)formal home care, medical<br /><br>consumption, mortality and costs per quality adjusted life years (QALYs). </p><br>