ACTRN12619000959178暂停1 期
Effect of probenecid on the pharmacokinetics of cefalexin in children
A/Prof Tony Walls0 个研究点目标入组 18 人开始时间: 2019年7月8日最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 暂停
- 发起方
- 入组人数
- 18
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Non-randomised trial
- 主要目的
- Treatment
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 2 Years 至 12 Years（—）
- 性别
- All
入选标准
- •Male and female children aged 2-12 years
- •under the care of the paediatric department at Christchurch hospital
- •prescribed cefalexin as oral follow-on to iv treatment for osteomyelitis, septic arthritis or other serious infection
- •have an iv line in place (most likely a PICC line) for blood sampling
- •receiving no other regular medicines likely to interact with either probenecid or cefalexin
排除标准
- •children for whom the blood volumes required poses above-minimal risk due to concurrent medical conditions such as anaemia (physician discretion)
- •contraindication to probenecid eg. hypersensitivity or disorders of uric acid metabolism
- •contraindication to cefalexin eg. hypersensitivity
- •taking methotrexate (if treatment is not interrupted while the infection is being treated)
- •history of significant renal or hepatic disease, or current significant abnormalities in renal or liver function tests.
- •Children with Cystic Fibrosis
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