ACTRN12607000247471已完成不适用
A Study of the Effect of Probenecid on the Pharmacokinetics and Pharmacodynamics of Allopurinol at Steady-State in Patients with Gout
Department of Clinical Pharmacology and Toxicology, St Vincent’s Hospital Sydney Ltd0 个研究点目标入组 50 人开始时间: 2007年5月8日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Non-randomised trial
- 主要目的
- Treatment
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- All
入选标准
- •Patients taking allopurinol for the indication of hyperuricaemia and/or gout.
排除标准
- •1. A history of sensitivity to allopurinol or probenecid2. A history of nephrolithiasis3. Patients taking drugs likely to interfere with the pharmacokinetics of allopurinol or probenecid including: salicylates (high doses) 4. Drugs likely to interact with probenecid including: valaciclovir, acyclovir, famiciclovir, penciclovir, ganciclovir, zidovudine, methotrexate, lorazepam, midazolam, nitrazepam. Note: Drugs which may affect plasma urate concentrations need to be taken consistently throughout the study to avoid biasing the plasma urate concentrations.
研究者
相似试验
已完成
不适用
The influence of probenecid on the metabolism of sorafenibHepatocellular carcinomathyroid carcinomarenal cell carcinoma HCC, hepatocellulair carcinoomRCC, NiercelcarcinoomSchildkliercarcinoomNL-OMON21261Erasmus MC16
进行中（未招募）
1 期
Observational study of the effects of probenecid on the metabolism and working mechanism of sorafenib (PROSORA-study)patients with unresectable hepatocellular cancer, advanced clear-cell renal cell carcinoma, locally recurrent or metastatic, progressive, differentiated thyroid carcinoma refractory to radioactive iodine treatment.EUCTR2017-002470-40-NLErasmus MC Cancer Institute16
已完成
2 期
An intervention study of the effects of probenecid on the pharmacokinetics and pharmacodynamics of sorafenib (PROSORA-study)Hepatocellular carcinomadifferentiated thyroid carcinomametastatic renal cell carcinoma10019815NL-OMON46801Erasmus MC, Universitair Medisch Centrum Rotterdam16
进行中（未招募）
不适用
Pharmacokinetic interactions between probenecid and the combination mycophenolate mofetil - cyclosporine/tacrolimus in stable renal allograft recipientsRenal transplant recipients treated with mycophenolate mofetil and tacrolimus.EUCTR2005-000012-27-BEDepartment of Nephrology and Renal Transplantation12
暂停
1 期
Effect of probenecid on the pharmacokinetics of cefalexin in childreantibiotic pharmacokineticsInfection - Other infectious diseasesACTRN12619000959178A/Prof Tony Walls18