Effect of the structured exercise intervention for dementia prevention on cognitive function in patients with mild cognitive impairment

Not Applicable

Conditions: Diseases of the nervous system

Registration Number: KCT0004619

Lead Sponsor: Ajou University

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot yet recruiting

Sex: All

Target Recruitment: 52

Inclusion Criteria

1. One or more of the following dementia risk factors:
1) Hypertension on medication
2) Diabetes mellitus on oral hypoglycemic agent or insulin
3) Dyslipidemia on medication
4) Obesity: BMI 25kg/m2 and above
5) Smoking: patients who have smoked at least 100 cigarettes in their lifetime and smoked more than 1 cigarette in the last month
6) Excessive drinking: more than 170 grams of alcohol per week
7) An educational background of less than 9 years
8) Aerobic exercise with moderate strength (3~6 METS) less than 150 minutes per week (more than 30 minutes, more than 5 days a weak) or high-intensity aerobic exercise (>6METS) less than 60 minutes per week (20 minutes or more, 3 days or more per week)
9) Insufficient strength exercise; do not perform 8 to 10 muscle group exercises for 10 to 15 repetitions per every exercise session for 2 days or more per week

2. No significant daily life dysfunction: KIADL 0.42 or below
3. The participant should not be dementia in the judgement of clinicians.
4. Literacy
5. Written consent to participate in the research

Exclusion Criteria

1. Mental illness such as major depression disorder
2. Dementia
3. Other neurodegenerative diseases such as Parkinson's disease
4. MMSE z-score -1.5 or less
5. Malignant tumors within 5 years of not being cured
6. Revascularization or stent insertion within 1 year
7. Severe or unstable symptomatic cardiovascular disease
8. Any other evidence of serious or unstable physical condition (acute or severe asthma, active gastrointestinal ulcer, severe liver disease or kidney disease enough to receive dialysis), patients with other medical conditions that may interfere with the completion of the clinical trial
9. Severe vision loss, severe hearing loss, or communication impairment beyond which intervention and validation cannot be performed
10. Illiteracy
11. In case it is deemed difficult to participate in the research in cooperation with the researchers' judgment to the end
12. In case of difficulty in safely participating in arbitration programs in the judgment of the researchers
13. Participation in other intervention studies

Study & Design

Study Type: Interventional Study

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
physical activity (muscle strength, balance, flexibility, cardiopulmonary endurance, cooperation);Neuropsychological test for cognitive evaluation;brain imaging (brain MRI for evaluating cortical thickness and activated brain area);Electroencephalogram;Blood biomarker (BDNF, anandamide, 2-arachidonoylglycerol)

Secondary Outcome Measures