The Safety and Effectiveness of Cidofovir in the Treatment of Venereal Warts in HIV-Infected Patients
- Conditions
- HIV InfectionsCondyloma Acuminata
- Registration Number
- NCT00002327
- Lead Sponsor
- Gilead Sciences
- Brief Summary
To evaluate the safety and tolerance of topical cidofovir (HPMPC) therapy for condyloma acuminatum in patients with HIV infection. To investigate whether topical HPMPC therapy can induce regression of condyloma acuminatum in patients with HIV infection.
- Detailed Description
Four groups of 10 patients each receive topical HPMPC at 0.3 percent concentration for 5 or 10 days total or 1.0 percent concentration for 5 or 10 days total, followed by 2 weeks of rest. When six patients at a given dose and schedule have completed treatment and follow-up without significant toxicity, subsequent patients are entered at the next higher dose level. Patients are evaluated twice weekly during treatment and once weekly during the rest period. HPMPC may be extended for up to two additional courses in patients who experience no significant toxicity.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (11)
Dr Brad Bowden
🇺🇸Houston, Texas, United States
Pacific Med Ctr
🇺🇸Seattle, Washington, United States
Houston Clinical Research Network
🇺🇸Houston, Texas, United States
East Bay AIDS Ctr
🇺🇸Berkeley, California, United States
Univ of Washington / Viral Disease Clinic
🇺🇸Seattle, Washington, United States
Univ of Utah School of Medicine
🇺🇸Salt Lake City, Utah, United States
Univ of Rochester Med Ctr
🇺🇸Rochester, New York, United States
Univ California San Francisco
🇺🇸San Francisco, California, United States
Bronx-Lebanon Hosp Ctr
🇺🇸Bronx, New York, United States
Dr Stephen Tyring
🇺🇸Nassau Bay, Texas, United States
City and County of Denver / Dept of Health & Hosps
🇺🇸Denver, Colorado, United States