Azithromycin in older people with airway disease

Phase 3

Completed

• Conditions: Asthma; Chronic obstructive pulmonary disease; Respiratory - Chronic obstructive pulmonary disease; Respiratory - Asthma

• Registration Number: ACTRN12609000259246
• Lead Sponsor: Hunter New England Area Health Service

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-05-13
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Symptomatic stable asthma or Chronic Obstructive Pulmonary Disease (COPD), increased sputum neutrophils.

Exclusion Criteria

Hypersensitivity to macrolides, other respiratory disease, taking macrolide, tetracycline, antibiotic or oral corticosteroid in past month, taking antacid treatment, taking medication that prolongs the heart's corrected QT interval (QTc), current smoking, pregnancy, impaired liver function.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Interleukin-8 (IL-8) concentrations in sputum supernatant, detected via the use of laboratory Enzyme Linked Immunosorbent Assay (ELISA) kits.[Assessed at randomisation and at the end of treatment.]