Evaluating the Effect of Epidural Clonidine as an Adjuvant to 0.5% Bupivacaine intrathecally in Combined Spinal Epidural Anaesthesia in lower limb orthopedic surgery.
Phase 4
Completed
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2022/04/042029
- Lead Sponsor
- Sawai Man Singh Medical College and Hospitals
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 62
Inclusion Criteria
Patients presenting for lower limb Orthopedic Surgery,Patient with ASA 1&2, scheduled for Elective Orthopedic Surgery
Exclusion Criteria
Patient Refusal, Patients with Significant Cardiovascular Disease,renal failure,hepatic dysfunction, chronic pulmonary disease and Diabetes mellitus,Neuromuscular disorder, Infection, Bleeding Disorder, Obesity( BMI >30kg/m2), History of Allergy or sensitivity to any of the study drug in previous surgery, Psychiatric illness, Antihypertensive therapy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mean Time of onset of Sensory Block at T10 dermatomesTimepoint: after 30 sec till 10 min
- Secondary Outcome Measures
Name Time Method Mean HR, SBP, DBPTimepoint: baseline, before CSE, just after CSE , 5min after CSE , 10 min, 15 min, 20 min then every 10 min till 90 min;Mean RAMSAY Sedation ScoreTimepoint: after 30 min of surgery, after 60 min, after 2hr of surgery then every 1hr till 6hr of surgery;Mean time of duration of motor blockTimepoint: intraoperative period and postoperative period;Mean time of onset of motor blockTimepoint: intaoperative period;Mean time of two segment regressionTimepoint: intraoperative period;Mean total duration of analgesiaTimepoint: intraoperative and postoperative period;Mean VAS ScoreTimepoint: after 30 min of surgery , after 60 min of surgery, after 2 hrs then every 1hr till 6hrs;Proportion of cases with side effectTimepoint: if any