Use of Cone Beam Kilovoltage Imaging in Patients Receiving Radiation Therapy for Head and Neck Cancer

Phase 2

Terminated

• Conditions: Head and Neck Neoplasms
• Interventions: Device: PTV Reduction

• Registration Number: NCT00358007
• Lead Sponsor: Sidney Kimmel Cancer Center at Thomas Jefferson University

Brief Summary

To evaluate the use of cone beam computed tomography in treating head and neck to hopefully reduce side effects

Detailed Description

The general purpose of this study is to evaluate Kilovoltage (kv) Imaging, specifically the Cone-beam CT (CBCT) scan device, to assess the accuracy of radiation therapy treatment delivery for patients with head and neck neoplasms

Study Timeline

• Study First Submitted: 2006-07-27
• Study First Submitted QC: 2006-07-27
• Study First Posted: 2006-07-28
• Study Start: 2007-03
• Primary Completion: 2008-02
• Study Completion: 2010-09
• Results First Submitted: 2014-06-12
• Results First Submitted QC: 2014-08-20
• Results First Posted: 2014-08-21
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-01
• Last Update Posted: 2025-05-04

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• any patient receiving radiation therapy for a head and neck tumor assigned to the new Elekta Synergy Linare Accelerator

Exclusion Criteria

• NA

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Cone Beam CT	PTV Reduction	-

Primary Outcome Measures

Name	Time	Method
Average Interfraction Shift of Patients Undergoing Radiotherapy	Daily prior to radiation	Determine the magnitude of the systematic error of patient positioning as determined by cone beam CT (CBCT) and the desired placement based on the treatment planning CT scan.; Every day, prior to radiation treatment, a CBCT will be performed. The CBCT images will be compared to the radiation therapy planning CT image just taken.
Average Residual Error Motion of Patients Undergoing Radiotherapy	Daily after each radiotherapy treatment	To determine the magnitude of random variance (random error) in radiotherapy treatment of head and neck neoplasms

Trial Locations

Locations (1)

Thomas Jefferson University; 🇺🇸 Philadelphia, Pennsylvania, United States