Awake Proning in Patients With COVID-19-Induced Acute Hypoxemic Respiratory Failure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 29
- 试验地点
- 1
- 主要终点
- Change in SpO2
研究概览
简要总结
The purpose of this study is to retrospectively review clinical data to determine whether awake proning improves oxygenation in spontaneously breathing patients with COVID-19 severe hypoxemic respiratory failure.
详细描述
Critically ill patients with coronavirus disease 2019 (COVID-19) severely strained intensive care resources in New York in April 2020. The prone position improves oxygenation in intubated patients with acute respiratory distress syndrome. The investigators wanted to study whether the prone position is associated with improved oxygenation and decreased risk for intubation in spontaneously breathing patients with severe COVID-19 hypoxemic respiratory failure. Awake prone positioning was implemented based on the health care provider decision.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Consecutive patients admitted to the Columbia University step-down unit from April 6,
- •Laboratory confirmed COVID-19 infection with severe hypoxemic respiratory failure defined as respiratory rate ≥30 breaths/min and oxyhemoglobin saturation (SpO2) ≤93% while receiving supplemental oxygen 6 L/min via nasal cannula and 15 L/min via non-rebreather facemask.
排除标准
- •Altered mental status with inability to turn in bed without assistance
- •Extreme respiratory distress requiring immediate intubation, or oxygen requirements less than specified in the inclusion criteria.
结局指标
主要结局
Change in SpO2
时间窗: Before proning and 1 hour after initiation of the prone position
SpO2 was measured by peripheral pulse oximetry.
次要结局
- Mean Risk Difference in Intubation Rates(Duration of hospitalization or up to 1 month from admission)
研究者
Sanja Jelic
Associate Professor of Medicine
Columbia University