Evaluation of modern MRI acceleration techniques for imaging of the brain and it's vascular supply at 1.5 T.

Conditions: G35
I67.10
Multiple sclerosis

Registration Number: DRKS00024403

Lead Sponsor: Institut für Radiologie und NeuroradiologieEvangelisches Krankenhaus OldenburgUniversitätsmedizin Oldenburg

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 63

Inclusion Criteria

General: persons with a minimum age of 18 years who are able to give informed consent

Subproject 1 and 2, Step 1: Healthy Volunteers

Subproject 1, Step 2: Patients with multiple sclerosis: Diagnosis of multiple sclerosis after the last revision (Thompson et al., Lancet Neurology 2018) of the McDonald's diagnostic criteria for multiple sclerosis or high clinical suspicion of MS with an appropriate clinical syndrome with at least 2 known T2-hyperintense lesions

Subproject 2, Step 2: Patients with untreated intracranial aneurysms: diagnosis of one or more intracranial aneurysms, of which at least one is untreated at the time of the MRI scan; additionally treated aneurysms (for example by means of clipping, coiling, stenting or with flow-diverters) provided that these don't represent a contraindication for an MRI scan

Exclusion Criteria

General:general contraindications for MRI, for example implants such as non-conditional MR-suitable pacemaker or auto-defibrillator, implanted neural stimulator, ocular metal foreign bodies (e.g. metal shards). Conditions that could hinder the conduct of the study (e.B. morbid obesity, pronounced claustrophobia), existing unnecessary risks (pregnancy, surgery of an unsafe nature).
Subproject 1 and 2, Step 1: Known serious diseases of the central nervous system

Subproject 1, Step 2: Known serious diseases of the central nervous system (except MS in the patient group)

Subproject 2, Step 2: Known serious diseases of the central nervous system (except intracranial aneurysms in the patient group) Note: neurovascular implants (aneurysm clips, coils, stents, flow diverters) are permitted when devices are classified as MR-safe or conditionally MR-safe if compliance with the required (i.e. manufacturer-recommended) examination conditions is guaranteed.