Coronary microvascular dysfunction and heart failure after TAVI

Recruiting

• Conditions: Aortic stenosis, Heart failure, Coronary microvascular dysfunction

• Registration Number: jRCT1052240127

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-09-18
• Last Update Posted: 2024-09-18

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Adults aged 20 years or older Patients with severe aortic valve stenosis who are eligible for TAVI treatment and are scheduled for TAVI Patients with stenosis findings or suspected stenosis on coronary CT prior to TAVI Cases where informed consent has been obtained from the patient for participation in the study

Exclusion Criteria

Presence of severe valvular disease (stenosis or regurgitation) other than aortic valve stenosis Patients who have undergone PCI during the pre-TAVI cardiac catheterization or are scheduled to undergo PCI postoperatively Patients deemed unsuitable for this study by the principal (or sub-investigator) physician

Study & Design

• Study Type: Observational
• Study Design: single assignment

Primary Outcome Measures

Name	Time	Method
-		CFR and IMR as indicators of coronary microvascular dysfunction before and after TAVI

Secondary Outcome Measures

Name	Time	Method
Correlation between wire-based IMR and angio-based IMR		Evaluation of the correlation between wire-based IMR and angio-based IMR
Transthoracic echocardiography		Assessment of the severity of various valvular diseases and left ventricular mass index
Cardiac MRI		Assessment of left ventricular mass index and Late Gadolinium Enhancement (LGE)