Foot Perfusion by Dynamic Contrast Enhanced MRI in Patients With Peripheral Artery Disease
Not yet recruiting
- Conditions
- Peripheral Arterial DiseasePerfusion
- Registration Number
- NCT06525415
- Lead Sponsor
- Fudan University
- Brief Summary
We investigate the peri-operative foot perfusion through dynamic contrast enhanced MRI in patients with peripheral artery disease
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- 18 to 80 years old;
- PAD patients with Fontaine grade II-IV or Rutherford grade 2-6 and underwent a successful revascularization;
- Patients completed both pre- and post-operative MRI workups;
- Patients signed the informed consent form and be able to complete the clinical follow-up for 1 months.
Exclusion Criteria
- Patients has participated in other clinical studies;
- Patients with Heart failure (NYHA III/IV)/right to left shunt heart disease/ severe aortic and mitral insufficiency/acute coronary syndrome/malignant arrhythmia/severe pulmonary hypertension (pulmonary artery pressure at least 90 mmHg)/moderate to severe renal insufficiency (creatinine clearance rate<60 ml/min)
- Any allergic constitution;
- Pregnancy and childbirth;
- Life expectancy<12 months.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method preoperative perfusion parameters Between Aug.1 2024 and OCT.31 2024 preoperative perfusion parameters by dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI)
- Secondary Outcome Measures
Name Time Method ankle brachial index Between Aug.1 2024 and OCT.31 2024 survival Between Aug.1 2024 and NOV.30 2024 clinical success Between Aug.1 2024 and NOV.30 2024
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie foot perfusion changes in peripheral artery disease as measured by DCE-MRI?
How does dynamic contrast enhanced MRI compare to ankle-brachial index in assessing foot perfusion in PAD patients?
Which biomarkers correlate with improved perfusion outcomes in DCE-MRI studies of peripheral arterial disease?
What adverse events are associated with DCE-MRI evaluation of foot perfusion in PAD populations?
Are there combination therapies with DCE-MRI that enhance revascularization in PAD patients?