Freeze All Strategy Versus Fresh Embryo Transfer After GnRH Analogue Trigger
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,396
- 主要终点
- ongoing pregnancy rate
研究概览
简要总结
Ovarian hyperstimulation syndrome (OHSS) is one of the most dangerous complications of assisted reproduction technology (ART), described in approximatively 3 to 10% of stimulation cycles although an underestimation of the real incidence has been suggested.
The use in clinical practice of GnRH antagonist has made it possible to perform the trigger with GnRH analogues, with the advantage of considerably reducing the risk of OHSS.
详细描述
The main concerns about the trigger with analogue are about obstetric outcomes, since it may increase the Abortion Rate (AR) and reduce the Ongoing Pregnancy Rate (OPR) due to luteal phase deficiency, and on the other hand about oocyte quality and competence.
While in order to maximize the chance of pregnancy at fresh embryo transfer after GnRHa trigger, several studies have focused on the importance of luteal phase support, other authors suggest that the best strategy is freeze-all: cryopreservation of all the obtained embryos and subsequent single embryo transfers.
However, data about oocyte quality, retrieval rate, pregnancy rate and reduced occurrence of complications such as OHSS, especially on the very first embryo transfer, are still scarce.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 20 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •patients undergoing ART cycle with antagonist protocol stimulation and trigger with GnRH agonist
- •patients are believed at risk of OHSS at time of trigger based on size and number of follicles developed (≥18 follicles with diameter 12 mm at induction).
排除标准
- •hypogonadotropic hypogonadism
- •other ART protocols
- •any patient that underwent freeze-all strategy in order to perform pre-implantation genetic testing (PGT)
- •oncological or deferring motherhood freezing procedures
结局指标
主要结局
ongoing pregnancy rate
时间窗: 8 years
number of viable pregnancies that had completed at least 12 weeks of gestation on the total number of ETs performed
delivery rate
时间窗: 8 years
number of deliveries of one or more live births over the total performed ET
次要结局
- Other pregnancy outcomes(8 years)
- Safety profile(8 years)
- the dropout rate(8 years)