Serum selenoprotein P and glutathione peroxidase levels in individuals with prediabetes and their association with insulin resistance and inflammatory markers - SELenium In Prediabetes (SELIP) trial

Research Society for Study of Diabetes in India West Bengal Chapter0 个研究点目标入组 200 人开始时间: 待定最近更新: 2021年11月24日

试验速览

暂无简介。

•Individuals with persistent impaired fasting glucose (IFG) (100-125mg/dl) and/or impaired glucose tolerance (IGT) (140-199mg/dl) over 2 oral glucose tolerance tests (OGTTS) done over a week using 75 gram anhydrous glucose were included

•Subjects with diabetes mellitus are excluded, i.e. FPG >= 126 mg/dl or 2-hour plasma glucose >= 200 mg/dl during OGTT,
•Hyperthyroid patients
•Medical conditions likely to limit life span and/or increase risk of intervention
•Cardiovascular disease
•Hospitalization for treatment of heart disease or stroke in past 6 months
•New York Heart Association Functional Class > 2
•Renal disease (creatinine >= 1.6 mg/dl for men or >= 1.5 mg/dl for women
•Hepatitis, based on history and/or serum ALT greater than 2.5 times the upper limit of normal
•Recent or significant abdominal surgery
•Pulmonary disease with dependence on oxygen or daily use of bronchodilators
•Chronic infection (e.g., HIV, active tuberculosis)
•Patients with history of selenium supplementation
•Pregnancy and childbearing
•Currently pregnant or within 3 months postpartum
•Currently nursing or within 6 weeks of having completed nursing
•Medications and medical conditions likely to confound the assessment for diabetes, including
•Thiazide diuretics at a dose greater than 25 mg/day
•Non-cardioselective beta-blockers, systemic
•Niacin (individuals receiving treatment with a statin or fenofibrate will not be excluded as long as the dose has been stable for 3 months prior to randomization)
•Glucocorticoids, systemic
•Prescription weight-loss or weight-gain medications

发起方

Research Society for Study of Diabetes in India West Bengal Chapter