The ECHOVID-19 Study - A Prospective Cohort Study Investigating the Acute Effect of COVID-19 on the Heart and Lung by Ultrasound
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 305
- 试验地点
- 1
- 主要终点
- Incident ARDS (Adult Respiratory Distress Syndrome) and intensive care unit admission during hospitalization and a confirmed COVID-19 diagnosis
研究概览
简要总结
The study is a prospective clinical cohort study of consecutive patients hospitalized at all hospitals of greater Copenhagen with a laboratory confirmed diagnosis of COVID-19. The investigators aim to examine if echocardiography - both conventional and advanced - can be used to predict which patients will develop acute respiratory distress syndrome (ARDS) or other short-term acute complications, especially focusing on cardiovascular outcomes. In addition, using a novel technique of lung ultrasound (LUS), The investigators aim to analyze specific LUS-findings, and associate them with short-term prognosis and development of ARDS and long-term cardiovascular morbidity and mortality. In all patients included, The investigators aim to examine long-term complications at timepoints: 2, 5 and 10 years of follow-up and examine if echocardiography - alone and in combination with biomarkers - can be used to detect early signs of cardiac complications and predict long-term risk of cardiovascular morbidity and mortality following COVID-19 infection
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients hospitalized at hospitals of greater Copenhagen area and Zealand with a laboratory confirmed diagnosis of COVID-19 > 18 years of age.
排除标准
- •Persons not able to cooperate
- •Persons unable to understand and sign "informed consent"
结局指标
主要结局
Incident ARDS (Adult Respiratory Distress Syndrome) and intensive care unit admission during hospitalization and a confirmed COVID-19 diagnosis
时间窗: 2.5 months
In-hospital mortality during hospitalization and a confirmed COVID-19 diagnosis
时间窗: 2.5 months
Incident hypoxic respiratory failure during hospitalization and a confirmed COVID-19 diagnosis
时间窗: 2.5 months
次要结局
- Death from any cause after hospital admission with a confirmed COVID-19 diagnosis at follow-up(2.5 months to 10 years)
- Incident myocardial infarction after hospital admission with a confirmed COVID-19 diagnosis at follow-up(2.5 months to 10 years)
- Incident heart failure after hospital admission with a confirmed COVID-19 diagnosis at follow-up(2.5 months to 10 years)
- Incident cardiac arrest during hospitalization and a confirmed COVID-19 diagnosis(2.5 months)
- Incident pulmonary embolism during hospitalization and a confirmed COVID-19 diagnosis(2.5 months)
- Incident stroke after hospital admission with a confirmed COVID-19 diagnosis at follow-up(2.5 months to 10 years)
研究者
Tor Biering-Sørensen
Associate professor and Research Director, Cardiovascular Non-Invasive Imaging Research Laboratory
University Hospital, Gentofte, Copenhagen