Effect of mashadi taila nasya and pathyadi kashaya in the management of migraine

Not yet recruiting

• Conditions: Metabolic disorder, unspecified. Ayurveda Condition: ARDHAVABEDAKAH,

• Registration Number: CTRI/2022/02/039906
• Lead Sponsor: Dr Deeksha R

Brief Summary

Ardhavabhedaka is one of the shirorogas characterized by severe pain in one half of the head which when not treated or poorly treated may lead to complications like destruction of eye and ears (Nayana and Sravana vinasha). Nasya is the main treatment indicated in all urdhwajatrugata rogas. The formulation, mashadi taila is indicated in all types of Shirorogas. Pathyadi Kashaya is specifically mentioned for Ardhavabedhaka. Drugs in Mashadi Taila posses the properties which are mainly vatahara (pacifies vata dosha), acts as shiroartinut (Pacifies headache). The drugs in Pathyadi Kashaya are tridoshahara and are specifically indicated for Ardhavabedhaka. Mashadi taila is a simple taila preparation with three ingredients and Pathyadi kashaya has eight drugs which can be easily procured. Hence, these two formulations have been selected to access their combined effect on Ardhavabedhaka (Migraine).

OBJECTIVES- To evaluate the combined effect of Mashadi Taila marsha nasya and pathyadi kashaya in the management of Ardhavabedaka with special reference to Migraine



METHODOLOGY

METHODOLOGY: Interventional clinical study

RESEARCH DESIGN Open labeled single arm prospective clinical trial

SOURCE OF DATA: 30 Patients will be selected from Out-patient department and In-patient department of Shalakya Tantra, Sri Dharmasthala Manjunatheshwara college of Ayurveda and Hospital, Hassan. SAMPLING TECHNIQUE: Convenient sampling

SAMPLE SIZE: 30

DIAGNOSTIC CRITERIA: Criteria for Diagnosing Migraine without Aura will be based on ICHD-3 1.119 A . At least five attacks fulfilling criteria B–D B . Headache attacks lasting 4–72 h (untreated or unsuccessfully treated) C . Headache has at least two of the following characteristics:  Unilateral location  Pulsating quality  Moderate or severe pain intensity  Aggravation by or causing avoidance of routine physical activity (e.g., walking or climbing stairs) D . During headache at least one of the following:  Nausea and/or vomiting  Photophobia and phonophobia E . Not better accounted for by another ICHD-3 diagnosis

INCLUSION CRITERIA ï‚· Patient who fulfill the diagnostic criteria ï‚· Patient of either gender of age between 18-60 years ï‚· Both fresh and treated case will be considered for the study

Exclusion Criteria: ï‚· Migraine with aura. ï‚· Severe depression or psychiatric disorders. ï‚· Referred pain in one half of head due to disorders of ear, eye, nose, teeth and neck. ï‚· Unilateral headache due to sinusitis, Hypertension. ï‚· All patients contraindicated for marsha nasya. ï‚· Patients who are using drugs like alcohol, chlorpromazine, hydrochlorothiazide, antianxiety agents, antidepressants, antipsychotics, antispasmodics, antihistamines and diuretics ï‚· Patients under continuation of other system of medication for migraine ï‚· Pregnant and lactating women

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2022-01-22
• Study Start: 2022-10-02

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Patient who fulfill the diagnostic criteria OF Ardhavabhedaka(Migraine) as quoted in Ayurveda samhithas and ICHD-3 Patient of either gender of age between 18 to 60 years Both fresh and treated case will be considered for the study Criteria for Diagnosing Migraine without Aura will be based on ICHD-3 1.119 A .
• At least five attacks fulfilling criteria B–D B .
• Headache attacks lasting 4–72 h (untreated or unsuccessfully treated) C .
• Headache has at least two of the following characteristics: ï‚· Unilateral location ï‚· Pulsating quality ï‚· Moderate or severe pain intensity ï‚· Aggravation by or causing avoidance of routine physical activity (e.g., walking or climbing stairs) D .
• During headache at least one of the following: ï‚· Nausea and/or vomiting ï‚· Photophobia and phonophobia E .
• Not better accounted for by another ICHD-3 diagnosis.

Exclusion Criteria

• Migraine with aura.
• Severe depression or psychiatric disorders.
• Referred pain in one half of head due to disorders of ear, eye, nose, teeth and neck.
• Unilateral headache due to sinusitis, Hypertension.
• All patients contraindicated for marsha nasya.
• Patients who are using drugs like alcohol, chlorpromazine, hydrochlorothiazide, anti-anxiety agents, antidepressants, antipsychotics, antispasmodics, antihistamines and diuretics Patients under continuation of other system of medication for migraine Pregnant and lactating women.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To evaluate the effect of mashadi taila nasya and pathyadi kashaya in ardhavabhedaka(migraine)	Baseline, 7th day, 14th day, 30th day

Secondary Outcome Measures

Name	Time	Method
To evaluate the effect of mashadi taila marsha nasya and pathyadi kashaya in ardhavabhedaka(migraine)	31st day

Trial Locations

Locations (1)

SDM college of ayurveda and hospital; 🇮🇳 Hassan, KARNATAKA, India

SDM college of ayurveda and hospital

🇮🇳Hassan, KARNATAKA, India

Dr Deeksha R

Principal investigator

9483483373

deeksha118@gmail.com