To study the effect of panchbhautika nasal drops in the patients with migraine

Phase 2/3

Not yet recruiting

• Conditions: Migraine, unspecified. Ayurveda Condition: ARDHAVABEDAKAH,

• Registration Number: CTRI/2025/04/084946
• Lead Sponsor: Parul Institute Ayurveda

Brief Summary

Introduction

Ardhavabhedaka  commonly known as a type of headache or migraine  is primarily caused by an imbalance in the Vata dosha, and in some cases, a combination of Vata and Kapha

according to the classical texts of Ayurveda  Acharya Charaka Sushruta  and Vaghbhata  this condition is associated with factors that aggravate Vata  including excessive consumption of dry or rough foods overeating  improper food combinations  excessive  sexual activity suppression of natural urges  and overexertion



The main symptoms include pain that affects half of the head Shira  particularly in areas such as the forehead temples  ears  eyes and neck  the condition is linked to an imbalance in the Vata dosha  which causes pain and discomfort in these regions  The disease is treated under the branch of Shalakya Tantra Urdhvanga Chikitsa  which focuses on disorders related to the head and sensory organs



In essence  ardhavabhedaka is a Vata dominated disorder  and managing it requires addressing the underlying causes that disturb the balance of Vata  with therapeutic approaches in Ayurveda focusing on balancing the doshas

Need for study

According to international headache society  migraine have influence on 16% of the primary headache In today’s era 10-20% of general population suffer from migraine  It is three times more common in women than men  3:1 in India more than 10 million cases per year  migraine can be a challenging disease to diagnose only based on subjective criteria and it is verifiable only by the patient



Treatment of Migraine such as Analgesics  Vasodilators available in present days  ancient Acharyas have described various types of Nasya in the management of ardhavabhedaka so there is a need to re-establish or to search effective medicine for Migraine

Detailed Description

Not available

Study Timeline

• Study Start: 2025-05-15
• Last Update Posted: 2025-12-04

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• 1.Patients will be enrolled in the study based on the diagnostic criteria for ardhavabhedaka migraine 2.
• Patients will be selected from 18-60 years Age group 3.
• Patients who will be fit for Pratimarsh Nasya karma.

Exclusion Criteria

• Patients of ardhavabhedaka migraine who are taking alternative medicines 2.
• Other known case of any systemic disease HTN COPD etc 3.
• Patients with conditions such as brain tumors meningitis cervical spondylitis encephalitis referred pain refractive errors or glaucoma will not be enrolled in this study 4.
• Contraindicated for nasal instillation Pratimarsh Nasya karma.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Ardhavabhedaka with Special reference to Migraine	At baseline on 15th day 30th day 45th day 60th day 75th day and 90th day
To Evaluate the Efficacy of Panchbhautika nasal drops in The Management of	At baseline on 15th day 30th day 45th day 60th day 75th day and 90th day

Secondary Outcome Measures

Name	Time	Method
relief from symptoms of migraine	90 days

Trial Locations

Locations (1)

Parul Ayurved Hospital; 🇮🇳 Vadodara, GUJARAT, India

Parul Ayurved Hospital

🇮🇳Vadodara, GUJARAT, India

Dr Chandni Dav

Principal investigator

6352863209

chandnidav000@gmail.com