Prostasin Levels in Preeclampsia: A Comparative Study With Healthy Pregnancies
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 88
- 试验地点
- 1
- 主要终点
- Maternal Serum Prostasin Levels
研究概览
简要总结
This study will aim to compare maternal serum prostasin levels between women diagnosed with preeclampsia and healthy normotensive pregnant controls. Participants will be divided into two main groups: those with preeclampsia and those with uncomplicated pregnancies. The preeclampsia group will further be subdivided based on the severity of the condition. Maternal serum samples will be collected from all participants, and prostasin levels will be measured using ELISA. Statistical analyses will be performed to evaluate whether prostasin levels are significantly elevated in the preeclampsia group, particularly in those with severe features, and to assess its potential as a biomarker for the condition.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Diagnosis of Preeclampsia: Defined by new-onset hypertension (systolic Blood Pressure ≥140 mmHg and/or diastolic Blood Pressure ≥90 mmHg) after 20 weeks of gestation, with or without proteinuria.
- •Control Group: Healthy pregnancies without preeclampsia or other significant maternal or fetal complications.
排除标准
- •Multiple Pregnancies
- •Pregestational Diabetes
- •Chronic Hypertension
- •Systemic Diseases (Chronic kidney disease, autoimmune diseases)
- •Fetal Anomalies
- •Premature Rupture of Membranes.
结局指标
主要结局
Maternal Serum Prostasin Levels
时间窗: Up to 8 weeks (Patients will be followed from inclusion in the study until the end of their pregnancy.
To compare Prostasin Levels between the pre-eclampsia and the control group.
次要结局
未报告次要终点
研究者
Gökhan Bolluk
MD
Başakşehir Çam & Sakura City Hospital