Characterization and Epigenetics of Post-Partum Preeclampsia
Trial Snapshot
- Phase
- Not Applicable
- Status
- Terminated
- Sponsor
- Duke University
- Enrollment
- 12
- Locations
- 2
- Primary Endpoint
- methylation signature on circulating monocytes
Study Overview
Brief Summary
This study will recruit women with post partum pre-eclampsia and match them to controls without postpartum pre-eclampsia to identify an epigenetic signature that is specific to women with post partum pre-eclampsia to help characterize the underlying pathophysiology of post partum pre-eclampsia.
Detailed Description
Preeclampsia (PEC) is a heterogeneous disease that complicates 5-8% of pregnancies. Approximately 10% of PEC patients will present with post-partum PEC without having developed the syndrome during the pregnancy (PP-PEC). Management of post-partum preeclampsia (PP-PEC) is challenging because many women do not seek care until neurologic symptoms result from severe-range elevated blood pressure. The pathogenesis and clinical characteristics of PP-PEC are understudied and poorly understood. Identifying clinical risk factors and biomarkers of PP-PEC would help to identify women at risk.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Post partum pre-eclampsia
- •Matching based on:
- •maternal age (years +/-3)
- •BMI (+/-5 points)
- •Ethnicity
- •Mode of delivery
- •Gestational age at delivery (+/7 days)
- •Smoking status
Exclusion Criteria
- •Intrapartum pre-eclampsia
Outcomes
Primary Outcomes
methylation signature on circulating monocytes
Time Frame: 1 week post delivery
Secondary Outcomes
No secondary outcomes reported