Characterization and Epigenetics of Post-Partum Preeclampsia
- Conditions
- Post Partum Pre-eclampsia
- Registration Number
- NCT02935556
- Lead Sponsor
- Duke University
- Brief Summary
This study will recruit women with post partum pre-eclampsia and match them to controls without postpartum pre-eclampsia to identify an epigenetic signature that is specific to women with post partum pre-eclampsia to help characterize the underlying pathophysiology of post partum pre-eclampsia.
- Detailed Description
Preeclampsia (PEC) is a heterogeneous disease that complicates 5-8% of pregnancies. Approximately 10% of PEC patients will present with post-partum PEC without having developed the syndrome during the pregnancy (PP-PEC). Management of post-partum preeclampsia (PP-PEC) is challenging because many women do not seek care until neurologic symptoms result from severe-range elevated blood pressure. The pathogenesis and clinical characteristics of PP-PEC are understudied and poorly understood. Identifying clinical risk factors and biomarkers of PP-PEC would help to identify women at risk.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- Female
- Target Recruitment
- 12
- Post partum pre-eclampsia
Matching based on:
- maternal age (years +/-3)
- BMI (+/-5 points)
- Ethnicity
- Mode of delivery
- Gestational age at delivery (+/7 days)
- Smoking status
- Intrapartum pre-eclampsia
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method methylation signature on circulating monocytes 1 week post delivery
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Columbia University Medical Center
🇺🇸New York, New York, United States
Duke University Medical Center
🇺🇸Durham, North Carolina, United States
Columbia University Medical Center🇺🇸New York, New York, United States