The impact of heart failure on exercise-induced cardiac fatigue: an explorative study

Completed

• Conditions: cardiovascular diseases; Heart failure; 10019280

• Registration Number: NL-OMON41066
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2015-12-31
• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

Heart failure group
- Participant of the Nijmegen 4-Day Marches 2014
- >=18 years
- Mentally able/allowed to give informed consent
- Patients diagnosed with systolic heart failure (including an ejection fraction <50% on current medication)
- NYHA class 1 + II;Control group
- Participant of the Nijmegen 4-Day Marches 2014
- >=18 years
- Mentally able/allowed to give informed consent

Exclusion Criteria

Heart failure group
- NYHA class III + IV
- Ejection fraction <25%;Control group
- Subjects diagnosed with the following cardiovascular diseases:
o Congenital heart disease
o Myocardial infarction
o Cerebrovascular incident
o Cerebral infarction

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Left ventricular ejection fraction, E/E* ratio and global longitudinal strain,<br /><br>RV fractional area change, E/E* ratio and global longitudinal strain are the<br /><br>primary outcome parameters in this study.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Cardiac biomarkers (high-sensitivity cardiac troponin, NT-proBNP, Galectin 3<br /><br>and ST2) and pulse wave velocity will be included as secondary outcome<br /><br>parameters</p><br>