Does a preload containing whey protein and guar (Omniblend) reduce the fall in blood pressure and affect the rate of stomach emptying after a sugary drink?

Phase 4

Completed

• Conditions: Postprandial hypotension; Cardiovascular - Other cardiovascular diseases; Metabolic and Endocrine - Diabetes; Diet and Nutrition - Other diet and nutrition disorders

• Registration Number: ACTRN12619000438156
• Lead Sponsor: Professor Karen Jones

Brief Summary

A whey protein/guar gum preload reduces postprandial glycaemia in type 2 diabetes through slowing gastric emptying. However, gastric emptying has previously been assessed using a stable isotope breath test technique, which cannot discriminate between slowing of gastric emptying and small intestinal absorption. This preload also may be useful in the management of postprandial hypotension. We evaluated the effects of a whey protein/guar preload on gastric emptying, glucose absorption, glycaemic/insulinaemic and blood pressure (BP) responses to an oral glucose load. Eighteen healthy older participants underwent measurements of gastric emptying (scintigraphy), plasma glucose and insulin, glucose absorption, superior mesenteric artery (SMA) flow, BP and heart rate (HR) after ingesting a 50 g glucose drink, with or without the preload. The preload significantly reduced plasma glucose concentrations and small intestinal glucose absorption, and increased plasma insulin levels. There was no difference in gastric emptying or BP between the two days. The reduction in plasma glucose on the preload day was related to the reduction in glucose absorption. In conclusion, the glucose-lowering effect of the preload may relate to delayed small intestinal glucose absorption and insulin stimulation, rather than slowing of gastric emptying.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-03-18
• Study Completion: 2019-05-28
• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

•Healthy subjects
•Body Mass Index 19-30 kg/m²

Exclusion Criteria

•History of diabetes mellitus (or fasting plasma glucose =7.0 mmol/L or HbA1C =6.5%)
•Severe respiratory or cardiovascular disease which would limit tolerance of study
•Hepatic disease as defined by transaminases more than 2 x upper limit of normal or bilirubin more than 2 X upper limit of normal
•Renal disease (creatinine clearance less than 50 mL/min)
•Anaemia or iron deficiency

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Blood pressure (BP) using automated BP cuff (DINAMAP ProCare 100, GE Medical Systems, Milwaukee, WI, USA). [ BP will be measured at 3 min intervals prior to administration of test drink, and then regularly at 5 min intervals from t = 5 - 180 min ];Heart rate (HR) using automated BP cuff (DINAMAP ProCare 100, GE Medical Systems, Milwaukee, WI, USA).[ HR will be measured at 3 min intervals prior to administration of test drink, and then regularly at 5 min intervals from t = 5 - 180 min ];Gastric emptying assessed by Scintigraphy[ Dynamic scintigraphic images will be acquired at 1 minute per frame for the first hour and at 3 minutes per frame for another two hours]