Evaluation of High-Density Lipoprotein in Obesity Study
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Obesity
- 发起方
- The Cleveland Clinic
- 入组人数
- 77
- 试验地点
- 1
- 主要终点
- To determine whether the functional activity of HDL is impaired in the setting of obesity
- 状态
- 终止
- 最后更新
- 9年前
概览
简要总结
Obesity is associated with an impaired functioning HDL (good cholesterol) resulting in an acceleration in the development of atherosclerosis. This study will evaluate HDL functionality in patients with BMI (Body Mass Index) 20 - 25 and BMI >30
详细描述
This study will determine if the protective function of high-density lipoprotein (HDL) is impaired in obese patients and will help to enhance cardiovascular risk prediction. Carotid intima-media thickness (cIMT) will be captured as a means of assessing early vascular changes associated with low HDL levels in obesity. A novel measurement for clinical correlation has also been introduced called carotid extra-medial thickness (cEMT) which will be compared to cIMT in this obese population.
研究者
入排标准
入选标准
- •Age 20-80
- •English speaking
- •BMI 20-25 kg/m2
- •Age 20-80
- •English speaking
- •BMI \> 30 kg/m2
- •TG \> 150 and
- •HDL \> 50 (females) \>40 (Males)
- •Age 20-80
- •English speaking
排除标准
- •Self-reported history of:
- •Diabetes mellitus
- •Any previous lipid therapy within the last three months
- •Macrovascular events including TIA, stroke, myocardial infarction, heart failure, claudication, or known peripheral vascular disease
- •Current pregnancy
结局指标
主要结局
To determine whether the functional activity of HDL is impaired in the setting of obesity
时间窗: Within 2 weeks of enrollment
次要结局
- To determine whether HDL is more susceptible to oxidative modification ex-vivo in obese patients by mass spectrometry(Within 2 weeks of enrollment)