Inflammatory Targeted Low-level Laser Treatment of Knee Osteoarthritis - A Randomized Clinical Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Knee Osteoarthritis
- Sponsor
- University of Bergen
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Pain in general
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
This study is conducted to evaluate the effectiveness of low-level laser therapy (LLLT) as an adjunct to exercise therapy in knee osteoarthritis (KOA).
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Pain in general
Time Frame: 0, 3, 8, 26 and 52 weeks after randomization
Pain in general is reported with the Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaire pain subscale. The subscale is based on Likert scales, each with five severity categories. The raw KOOS score is transformed to a 0-100 percentage score (higher is better).
Pain on movement
Time Frame: 0, 3, 8, 26 and 52 weeks after randomization
The participants are asked to rate their pain experienced on movement using an unidimensional visual analogue scale (VAS). "No pain" (0) is written in one end and "worst imaginable pain" (100) is written in the other end of the VAS tool.
Pain at night
Time Frame: 0, 3, 8, 26 and 52 weeks after randomization
The participants are asked to rate their pain experienced in bed at night using an unidimensional visual analogue scale (VAS). "No pain" (0) is written in one end and "worst imaginable pain" (100) is written in the other end of the VAS tool.
Pain at rest
Time Frame: 0, 3, 8, 26 and 52 weeks after randomization
The participants are asked to rate their pain experienced at rest in sitting position using an unidimensional visual analogue scale (VAS). "No pain" (0) is written in one end and "worst imaginable pain" (100) is written in the other end of the VAS tool.
Secondary Outcomes
- Physical function in sports and recreational activities(0, 3, 8, 26 and 52 weeks after randomization)
- Real time ultrasonography assessment of neovascularization(0, 3, 8, 26 and 52 weeks after randomization)
- 30 seconds chair stand(0, 3, 8, 26 and 52 weeks after randomization)
- Tibia bone pain pressure threshold(0, 3, 8, 26 and 52 weeks after randomization)
- Real time ultrasonography assessment of femur cartilage thickness(0, 3, 8, 26 and 52 weeks after randomization)
- Knee extension active range of motion(0, 3, 8, 26 and 52 weeks after randomization)
- Maximum pain free isometric quadriceps strength(0, 3, 8, 26 and 52 weeks after randomization)
- Joint line pain pressure threshold(0, 3, 8, 26 and 52 weeks after randomization)
- Physical function in daily living(0, 3, 8, 26 and 52 weeks after randomization)
- Quality of life(0, 3, 8, 26 and 52 weeks after randomization)
- Global health status assessment(8 weeks after randomization)
- Real time ultrasonography assessment of effusion(0, 3, 8, 26 and 52 weeks after randomization)
- Knee flexion active range of motion(0, 3, 8, 26 and 52 weeks after randomization)
- Analgesic drug consumption due to knee pain(0, 3, 8, 26 and 52 weeks after randomization)