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Clinical Trials/NCT06589453
NCT06589453
Not yet recruiting
Phase 1

Evaluation of Nasal Elevator Versus Grayson's Nasal Stent in Conjunction with Digital Nasoalveolar Molding (D-NAM) Appliance on Nasolabial Esthetics in Infants with Bilateral Cleft Lip and Palate: a Randomized Clinical Trial

Cairo University0 sites20 target enrollmentNovember 1, 2024

Overview

Phase
Phase 1
Intervention
Not specified
Conditions
Cleft Lip and Cleft Palate
Sponsor
Cairo University
Enrollment
20
Primary Endpoint
Nasolabial esthetics
Status
Not yet recruiting
Last Updated
last year

Overview

Brief Summary

Newborns with bilateral cleft lip/ palate will be treated pre-surgically by either nasal elevator or Grayson nasal stent in conjunction with digital nasoalveolar molding (D-NAM) appliance in order to evaluate their effect on the nasolabial esthetics.

Detailed Description

The aim of this trial is to evaluate and compare the short-term effect of nasal elevator with Grayson nasal stent in conjunction with digital nasoalveolar molding appliances at 2 stages T1 (Before NAM therapy), and T2 (After NAM therapy) as regards nasolabial esthetics and maxillary arch changes. Newborns with Bilateral cleft lip/ palate will be allocated randomly into two groups: the first group will receive nasal elevator with digital nasoalveolar molding appliance while the second group will receive Grayson nasal stent with digital nasoalveolar molding appliance. The follow-up period will be 4-6 months till surgical lip closure. The nasolabial esthetics will be assessed using facial scans and 2D photographs, while changes in the maxillary arch will be assessed by digital maxillary models.

Registry
clinicaltrials.gov
Start Date
November 1, 2024
End Date
October 1, 2026
Last Updated
last year
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

: Donia Ayman Ahmed Ezzeldin ElSayed

Assistant lecturer at Orthodontic Department, Cairo University

Cairo University

Eligibility Criteria

Inclusion Criteria

  • Non-syndromic Infants with complete BCLP infants
  • Infants less than 1 month of age.
  • Males and females.
  • Infants with displaced premaxilla
  • Patients whose parents provided written consent for the study.

Exclusion Criteria

  • Patients above 1 month of age.
  • Syndromic and systemically ill infants.
  • Patients with unilateral cleft lip and palate.
  • Incomplete Cleft lip or Simonart band (soft tissue bridge at the cleft side).
  • Medically compromised patients
  • Patien parents/guardians who will be unwilling to go through the Naso-alveolar molding (NAM) therapy.

Outcomes

Primary Outcomes

Nasolabial esthetics

Time Frame: 4-6 months

Columellar length is to be measured in millimeters digitally using facial scans before and after Nasoalveolar Molding therapy.

Secondary Outcomes

  • Maxillary arch changes(4-6 months)

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