Efficacy of prucalopride for improving motor fluctuations in patients with Parkinson’s disease

Not Applicable

• Conditions: Parkinson' s disease patient who have motor fluctuation; - Prucalopride; 5- HT4 receptor agonist; gastric emptying time; parkinson’s disease; motor fluctuation

• Registration Number: TCTR20180808002
• Lead Sponsor: /A

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-08-08
• Study Completion: 2018-12-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1.Age 18 years old or older
2.Fulfilled the UK Parkinson’s Disease Brain Bank criteria for PD
3. motor fluctuation by 9 item wearing off questionnaire
4.No anti-PD medication adjustment within the past 3 months

Exclusion Criteria

1.Presence of diabetes mellitus, chronic renal diseases, chronic liver disease, thyroid diseases or connective tissue disorders
2. Dementia
3. QT prolongation
4. Previous history of ventricular arrhythmia or myocardial infarction
5. Cirrhosis child pugh turcotte class C
6.Previous history of gastric surgery
7.Previous history of prolactinoma
8.Pregnant or lactating woman
9.Allergy to egg, prucalopride

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
percent of daily on time Within 24 hours after taking the drug on average in 7 days patient assessment

Secondary Outcome Measures

Name	Time	Method
nified Parkinson’s Disease Rating Scale(UPDRS) part III after taking drug 1 hour at day 0 and day 28 Neurologist assessment ,gastric emptying time after taking drug 1 hour at day 0 and day 28 gastric emptying scintigraphy,the Gastroparesis Cardinal Symptom Index at day 0 and day 28 patient assessment,side effect of prucalopride at day 28 patient assessment