Perception of the Doctor/Patient Relationship, Disease and Treatment Among Physicians and Their Patients Treated With Systemic Therapy for Hepatocellular Carcinoma "PERCEPTION1"

Completed

• Conditions: Hepatocellular Carcinoma

• Registration Number: NCT04823754
• Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Brief Summary

atients with cancer face difficult choices that require balancing competing priorities such as survival, functional capacity and symptom relief. Most patients with advanced cancer (\>80%) expect their sensitive discussions with physicians about prognosis and treatment choices, in order to be involved in the decision making process. Nevertheless, this kind of discussion is frequently lacking. Consequently, patients often have a biased view of their own prognosis such as an underestimation of disease severity, or unrealistic expectations for cure.

Patients with advanced hepatocellular carcinoma (HCC) may be treated with systemic therapies which may prolong survival, but are not curative. Patients with advanced HCC often report expectations for survival and treatment-related side-effects that differ from their treating physician. Accordingly, communication on prognostic and treatment choices is essential to obtain an accurate understanding of the disease that allows patients to make informed decisions. To the best of our knowledge, a thorough evaluation of the physician-patient communication quality has never been performed in advanced HCC patients.

The aim of our study, is to assess the perception of the expected prognosis, the treatment side-effects; by the patient and by his investigator during the first consultation before the initiation

Detailed Description

atients with cancer face difficult choices that require balancing competing priorities such as survival, functional capacity and symptom relief. Most patients with advanced cancer (\>80%) expect their sensitive discussions with physicians about prognosis and treatment choices, in order to be involved in the decision making process. Nevertheless, this kind of discussion is frequently lacking. Consequently, patients often have a biased view of their own prognosis such as an underestimation of disease severity, or unrealistic expectations for cure.

Patients with advanced hepatocellular carcinoma (HCC) may be treated with systemic therapies which may prolong survival, but are not curative. Patients with advanced HCC often report expectations for survival and treatment-related side-effects that differ from their treating physician. Accordingly, communication on prognostic and treatment choices is essential to obtain an accurate understanding of the disease that allows patients to make informed decisions. To the best of our knowledge, a thorough evaluation of the physician-patient communication quality has never been performed in advanced HCC patients.

The aim of our study, is to assess the perception of the expected prognosis, the treatment side-effects; by the patient and by his investigator during the first consultation before the initiation

Study Timeline

• Study First Submitted: 2021-03-26
• Study First Submitted QC: 2021-03-26
• Study First Posted: 2021-04-01
• Study Start: 2021-07-12
• Primary Completion: 2022-11-04
• Study Completion: 2022-11-04
• Status Verified: 2023-06
• Last Update Submitted: 2023-07-10
• Last Update Posted: 2023-07-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

1. Patient over 18 years of age
2. Patient informed and not objecting to participate in the study
3. Patient with advanced hepatocellular carcinoma.
4. Patient treated with systemic therapy

Exclusion Criteria

1. Locoregional treatment combined with systemic treatment
2. Pregnancy in progress
3. Candidate for surgery or locoregional therapy
4. Patient with state medical aid (AME)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Evaluate the concordance between the patient's perception of his prognosis and treatment side effects with the one of his treating physician.	12months	Use of survey completed by the patient and the doctors to assess the primary endpoint

Secondary Outcome Measures

Name	Time	Method
Evaluation of patient satisfaction with the information received during the consultation	12 months	Use of survey completed by the patient and the doctors to assess the primary endpoint
Compare the patient's expectations for the aforementioned items to those of his physician and the degree of concordance between them.	12 months	Use of survey completed by the patient and the doctors to assess the primary endpoint
Assessment of patient-reported symptoms of anxiety and depression	12 months	Use of survey completed by the patient and the doctors to assess the primary endpoint
Evaluate the association between individual prognosis expectation (patient and physician) and data from the available literature.	12 months	Use of survey completed by the patient and the doctors to assess the primary endpoint

Trial Locations

Locations (2)

Hôpital Avicenne; 🇫🇷 Bobigny, France

Assistance Publique - Hôpitaux de Paris; 🇫🇷 Paris, France